Tetrahydroaminoacridine and D-cycloserine stimulate acquisition of water maze spatial navigation in aged rats

European Journal of Pharmacology
J AuraP Riekkinen

Abstract

We investigated the effect of tetrahydroaminoacridine, a cholinesterase inhibitor and D-cycloserine (a partial glycine-B agonist of the NMDA receptor complex) on the defect of water maze spatial navigation in rats induced by aging. Tetrahydroaminoacridine (3 mg/kg, i.p.) or D-cycloserine (10 mg/kg, i.p.) enhanced acquisition of the water maze task. A combination of subthreshold doses of tetrahydroaminoacridine (1 mg/kg) and D-cycloserine (3 mg/kg) improved water maze acquisition, but a combination of lower subthreshold doses (tetrahydroaminoacridine 0.3 mg/kg + D-cycloserine 1 mg/kg) was ineffective. Consolidation in water maze test was not improved by tetrahydroaminoacridine (3 mg/kg) and/or D-cycloserine (10 mg/kg). The results suggest that tetrahydroaminoacridine and D-cycloserine synergistically enhance acquisition of spatial navigation in aged rats.

References

Apr 1, 1995·Current Opinion in Neurobiology·T G Aigner
Mar 1, 1994·Neurobiology of Aging·M G BaxterD S Olton
Feb 14, 1998·Neuroscience·M RiekkinenP Riekkinen

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Citations

Aug 11, 2007·Amino Acids·B SunyerG Lubec
Jun 16, 2004·Behavioural Brain Research·Eric M StoufferBryan D Devan
Nov 24, 1999·Brain Research. Brain Research Reviews·T C Foster
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Aug 13, 2013·PloS One·Marta Portero-TresserraAnna Vale-Martínez
Sep 7, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin K OgdenScott A Heldt
Sep 7, 2001·Neuropharmacology·V LelongM Boulouard
Mar 6, 2015·Journal of Pharmaceutical and Biomedical Analysis·Jean-Marie Billard
Apr 21, 2007·The European Journal of Neuroscience·J-M Billard, E Rouaud
Oct 22, 2008·Pharmacology, Biochemistry, and Behavior·Rachel A Davenport, Thomas A Houpt
Sep 21, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·E PlouxJ-M Billard

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