Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus

Brain Research
J Wu, G Z Jin

Abstract

In the patch-clamp perforated whole-cell recording mode, tetrahydroberberine (THB), a novel dopamine (DA) receptor antagonist, inhibits not only DA-induced outward K+ currents, but also acetylcholine-, caffeine- or strychnine-induced outward current. However, THB does not affect either GABA- or glycine-induced Cl- currents, or non-NMDA receptor agonist-induced cation currents. As expected for a K+ channel blocker, THB evokes a downward current deflection accompanied by a decrease of conductance. It is concluded that the direct blockade of membrane K+ channels by THB underlies its inhibition of intracellular message-mediated outward currents.

Citations

Sep 24, 2015·Pharmacological Reports : PR·Touqeer AhmedSeyed Mohammad Nabavi
Nov 24, 2011·Experimental Neurobiology·Taehwan LeeYunhee Kim Kwon
Jun 11, 2011·The Journal of Pharmacology and Experimental Therapeutics·Tae Ho LeeMirim Jin
May 8, 2018·Phytotherapy Research : PTR·Xiaorui Lin, Nan Zhang

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