Tetrahydrobiopterin in cardiovascular health and disease

Antioxidants & Redox Signaling
Jennifer K BendallMark J Crabtree

Abstract

Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthesis and recycling, versus degradation in the setting of oxidative stress. Augmenting vascular BH4 levels by pharmacological supplementation has been shown in experimental studies to enhance NO bioavailability. However, it has become more apparent that the role of BH4 in other enzymatic pathways, including other NOS isoforms and the aromatic amino acid hydroxylases, may have a bearing on important aspects of vascular homeostasis, inflammation, and cardiac function. This article reviews the role of BH4 in cardiovascular development and homeostasis, as well as in pathophysiological processes such as endothelial and vascular dysfunction, atherosclerosis, inflammation, and cardiac hypertrophy. We discuss the therapeutic potential of BH4 in cardiovascular disease states and attempt to address how this modulator of intracellular NO-redox balance may ultimately provide a powerful new treatment for many cardiovascular disea...Continue Reading

References

Oct 12, 1992·Neuroscience Letters·C Hölscher, S P Rose
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J GiovanelliS Kaufman
Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
Oct 1, 1990·Critical Care Medicine·J E Parrillo
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R IyengarM A Marletta
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Apr 14, 1988·Biochimica Et Biophysica Acta·R S ShenY X Zhang
Jan 1, 1964·Biochemical and Biophysical Research Communications·T NagatsuS Udenfriend
May 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·J B ClarkW N Shaw
Jul 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A FaggiottoL Harker
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A NicholD S Duch
Jan 1, 1993·Advances in Experimental Medicine and Biology·G Werner-FelmayerH Wachter
Nov 1, 1994·Journal of Leukocyte Biology·Q Xie, C Nathan
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L BalligandT Michel
Apr 13, 1995·Nature·S A ThomasR D Palmiter
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·Y NakashimaR Ross
Dec 1, 1993·Pharmacology, Biochemistry, and Behavior·L B EstallG A Cicala
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
May 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·E R WernerH Wachter
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·H J ChoC Nathan
Jan 1, 1996·Reviews of Physiology, Biochemistry and Pharmacology·E R WernerB Mayer
Mar 7, 1996·Biochemical and Biophysical Research Communications·A J BuneH T Cook
May 24, 1996·Biochemical and Biophysical Research Communications·C RibiereY Giudicelli
Aug 16, 1996·The Journal of Biological Chemistry·S MilstienT I Bonner
Sep 1, 1996·Metabolism: Clinical and Experimental·M AviramR Levy
Jan 1, 1996·Methods in Enzymology·Q Liu, S S Gross

❮ Previous
Next ❯

Citations

Jul 24, 2015·Expert Review of Cardiovascular Therapy·Andrew BinderIon S Jovin
Nov 6, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sylvain BattaultGrégory Meyer
Dec 22, 2015·Coordination Chemistry Reviews·Debashree BasudharDavid A Wink
Aug 31, 2014·Free Radical Biology & Medicine·Elizabeth J ReverriFrancene M Steinberg
Nov 21, 2014·Cardiovascular Drugs and Therapy·Dimitris TousoulisChristodoulos Stefanadis
Jun 15, 2016·Scientific Reports·Hsiang-En WuZhi-Dong Ge
Feb 6, 2017·Human Molecular Genetics·Jin-Song ShenTeodoro Bottiglieri
Jul 30, 2015·The Australian and New Zealand Journal of Psychiatry·Isabelle Granville SmithUté Vollmer-Conna
Mar 24, 2018·Scandinavian Cardiovascular Journal : SCJ·Ruha CerratoFelix Böhm
Jan 20, 2018·Antioxidants & Redox Signaling·Thomas MünzelAndreas Daiber
Jan 27, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shalini Jamwal, Saurabh Sharma
Aug 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna DikalovaCandice D Fike
Jul 13, 2018·Expert Review of Proteomics·Christian DellesStuart A Nicklin
Mar 24, 2016·Journal of the American Heart Association·Toru HashimotoDavid A Kass
Mar 31, 2015·Circulation Research·Guy EelenPeter Carmeliet
Sep 19, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhejun CaiMing-Hui Zou
Oct 21, 2018·Medicinal Research Reviews·Violeta Carmona-MartínezPilar García-Peñarrubia
Jan 10, 2019·International Journal of Molecular Sciences·Andreas DaiberHuige Li
Aug 2, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Prakash SeppanSathya Bharathy Sathyanathan
Jul 28, 2019·British Journal of Pharmacology·Konstantina Chachlaki, Vincent Prevot
Nov 24, 2017·Physiological Reviews·Guy EelenPeter Carmeliet
Nov 30, 2019·Alcoholism, Clinical and Experimental Research·Chueh-Lung HwangShane A Phillips
Feb 20, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna DikalovaCandice D Fike
Jul 4, 2020·ESC Heart Failure·Wei-Siang ChenChung-Yu Liang

❮ Previous
Next ❯

Methods Mentioned

BETA
electron paramagnetic resonance
coronary artery bypass
transgenic
transfection

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.