Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure.

Neuroscience Bulletin
Hong-Bo LuoQi-Dong Yang

Abstract

Excessive aluminum (Al) exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential linkage between chronic Al exposure and Alzheimer's disease. The present study aims to evaluate the effects of tetrahydroxy stilbene glucoside (TSG), the extract from herbal medicine Polygoni Multiflori, on cognitive impairment and the over-expression of hippocampal amyloid precursor protein (APP) induced by chronic exposure to Al in rats. Rats were treated with 0.3% aluminum chloride (AlCl3) prepared in the drinking water for 90 d. AlCl3-treated animals were then randomly assigned to receive vehicle, TSG (4 g/kg), or Vitamin E (VE; 40 mg/kg) treatment for 5 months. VE served as a positive control. The effect of TSG was evaluated by passive avoidance task, and APP expression was evaluated by Western blotting. Following exposure to AlCl3 for 90 d, animals displayed a striking decrease (> 80%) in step-through latency in the passive avoidance task and a significant increase in the expression of APP in the hippocampus. Both TSG and VE significantly ameliorated the performance impairment in the passive avoidance task, and suppressed the over-expression of APP. Moreover, the effects of TSG, but not of V...Continue Reading

References

Jan 1, 2000·Occupational and Environmental Medicine·R AkilaV Riihimäki
Mar 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·A CampbellS C Bondy
Nov 7, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P Nayak, A K Chatterjee
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ashley I Bush, Rudolph E Tanzi
Jun 26, 2003·The International Journal of Biochemistry & Cell Biology·Yan LingNoor Kalsheker
Jul 2, 2005·Cellular and Molecular Life Sciences : CMLS·F RicchelliP Zatta
Nov 26, 2005·Journal of Alzheimer's Disease : JAD·Masahiro Kawahara
Aug 18, 2006·Journal of Alzheimer's Disease : JAD·John Hardy
Oct 10, 2006·Biochemical and Biophysical Research Communications·Yoichiro NishidaHidehiro Mizusawa
Nov 23, 2006·Journal of Alzheimer's Disease : JAD·Arezoo Campbell
Nov 23, 2006·Journal of Alzheimer's Disease : JAD·Andrei C Miu, Oana Benga
Feb 17, 2007·Neurotoxicology·Bettina PlattAthanasios Salifoglou
Dec 7, 2007·The International Journal of Biochemistry & Cell Biology·Denise DragoPaolo Zatta
Mar 29, 2008·Neuroscience Bulletin·Xiao-Ping Wang, Hong-Liu Ding
Aug 1, 2008·Archives of Toxicology·Sandra V VerstraetenPatricia I Oteiza
Oct 8, 2008·Neuroscience Bulletin·Ying WanSheng-Di Chen

❮ Previous
Next ❯

Citations

Dec 25, 2012·Environmental Science and Pollution Research International·Khaleeq AnwarAqeel Javeed
Aug 13, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rasha M Abd-ElhadyAmani E Khalifa
Jan 30, 2015·Neurochemical Research·Arokiasamy Justin ThenmozhiThamilarasan Manivasagam
Dec 12, 2012·Fitoterapia·Qiao-Li LiangJin-Ao Duan
Nov 10, 2016·Ageing Research Reviews·Pu Wang, Zhan-You Wang
Jan 30, 2016·Environmental Health Perspectives·Tongjian CaiJingyuan Chen
Sep 17, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Abdullah Al MamunJian Xiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.