Tetrahymena basal bodies

Cilia
Brian A BaylessChad G Pearson

Abstract

Tetrahymena thermophila is a ciliate with hundreds of cilia primarily used for cellular motility. These cells propel themselves by generating hydrodynamic forces through coordinated ciliary beating. The coordination of cilia is ensured by the polarized organization of basal bodies (BBs), which exhibit remarkable structural and molecular conservation with BBs in other eukaryotes. During each cell cycle, massive BB assembly occurs and guarantees that future Tetrahymena cells gain a full complement of BBs and their associated cilia. BB duplication occurs next to existing BBs, and the predictable patterning of new BBs is facilitated by asymmetric BB accessory structures that are integrated with a membrane-associated cytoskeletal network. The large number of BBs combined with robust molecular genetics merits Tetrahymena as a unique model system to elucidate the fundamental events of BB assembly and organization.

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Citations

Nov 4, 2016·The Journal of Cell Biology·Brian A BaylessChad G Pearson
Oct 30, 2016·Traffic·Sabrice GuerrierAaron P Turkewitz
Jun 3, 2016·Molecular Biology of the Cell·Janet B MeehlMark Winey
Jul 13, 2019·Cells·Vladimir Joukov, Arcangela De Nicolo
May 22, 2020·The Journal of Cell Biology·Marisa D RuehleChad G Pearson
Nov 19, 2019·Frontiers in Cell and Developmental Biology·Brian A BaylessMark Winey
Jan 19, 2021·Seminars in Cell & Developmental Biology·Swadhin Chandra Jana
Aug 26, 2021·IScience·Anthony D JunkerChad G Pearson

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Methods Mentioned

BETA
dissection
light microscopy

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