PMID: 11339130May 8, 2001Paper

Tetralogy of Fallot in monozygotic twins

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
V LaugelM Fischbach

Abstract

The causative mechanisms of congenital heart defects remain unclear and little is known about the respective implication of chance, genetics and environment, though recent findings in molecular biology may provide further insight into understanding the pathophysiologic basis of congenital heart diseases. We report the exceptional but significant case of monozygotic twins both affected by tetralogy of Fallot, for whom prenatal diagnosis ruled out 22q11 microdeletion. We discuss how far this observation is consistent with the latest hypothesis, which emphasizes the leading role of genetic factors. Several genes indeed, either separately or in combination, could be responsible for those defects, even if other influences may still come into play.

Citations

Jul 2, 2011·Congenital Heart Disease·Henrik JensenVibeke E Hjortdal
Feb 24, 2006·Fetal Diagnosis and Therapy·J HajduZ Papp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
R Okada
Indian Heart Journal
Archana B Patel, Ramesh L Renge
Nihon rinsho. Japanese journal of clinical medicine
R Okada, S Kawai
Nihon rinsho. Japanese journal of clinical medicine
M Ando
The Journal of the Oklahoma State Medical Association
W M ThompsonG R Williams
© 2021 Meta ULC. All rights reserved