Tetramethylpyrazine enhances vascularization and prevents osteonecrosis in steroid-treated rats

BioMed Research International
Yini JiangNa Lin

Abstract

Steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH) is an avascular necrosis disease of bone. Tetramethylpyrazine (TMP), with significant vascular protective properties, has been widely used for the treatments of ischemic neural disorders and cardiovascular diseases. However, its role in the treatment of steroid-induced ONFH has not been evaluated. In this study, our results showed that TMP significantly decreased the ratio of empty lacuna, adipose tissue area, and adipocyte perimeter in steroid-induced ONFH rats histopathologically. TMP also reduced the levels of serum lipid dramatically by haematological examination. According to the micro-CT quantification, TMP could improve the microstructure of the trabecular bone and increases bone mineral density in steroid-induced ONFH rats. Moreover, TMP significantly increased the vessel volume, vessel surface, percentage of vessel volume, and vessel thickness of the femoral heads by micro-CT. Interestingly, the downregulation of VEGF and FLK1 proteins in the sera and necrotic femoral heads could be reversed by TMP treatment, and this was true for their mRNA expressions in femoral heads. In conclusion, these findings suggest for the first time that TMP may prevent...Continue Reading

References

Mar 1, 1995·The Journal of Bone and Joint Surgery. American Volume·M A Mont, D S Hungerford
Apr 4, 2001·The Journal of Bone and Joint Surgery. British Volume·W DrescherC Bünger
Nov 14, 2002·Seminars in Arthritis and Rheumatism·Yehudith Assouline-DayanM Eric Gershwin
Nov 9, 2004·Neuroscience Letters·Su-Lan LiaoChun-Jung Chen
Mar 1, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kosuke KatsubePatricia F Friedrich
Sep 23, 2006·Endothelium : Journal of Endothelial Cell Research·Mohammad Amin KerachianChantal Séguin
Nov 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Wolf DrescherEbbe-Stender Hansen
Jan 16, 2007·Burns : Journal of the International Society for Burn Injuries·Shan GaoXu-Lin Chen
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Stephen G BallCay M Kielty
Jan 15, 2009·Clinical Orthopaedics and Related Research·Sandeep BiswalWon Yong Shon
Mar 5, 2009·The Journal of Bone and Joint Surgery. British Volume·A V KorompiliasP N Soucacos
Jul 2, 2010·Calcified Tissue International·Ning HanZhiyong Zhang
Oct 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomoaki MikamiTadami Matsumoto
May 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wolf DrescherFrank Eitner
Jun 21, 2011·Modern Rheumatology·Tamon KabataHiroyuki Tsuchiya
Oct 1, 2011·BMC Musculoskeletal Disorders·Shuai DingZhe Wang
Dec 16, 2011·Endocrine·Robert S Weinstein
May 3, 2014·Molecular Medicine Reports·Mingshun ZhangChunbing Zhang

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