PMID: 8950300Jan 1, 1996Paper

Tetrandrine, a calcium antagonist of Chinese herbal origin, interacts with vascular muscle alpha 1-adrenoceptor

Life Sciences
C Y KwanS C Hui

Abstract

The effects of tetrandrine (TET) on the contractile responses of rat aortic rings and perfused rat mesenteric arteries to phenylephrine (PE) were investigated. TET inhibited the maximal contraction to PE in a concentration-dependent manner. TET significantly inhibited the transient contraction in Ca(2+)-free medium presumably due to release of intracellular Ca2+ after activation of alpha 1-adrenoceptors. However, it caused a stronger inhibition of the sustained contraction in Ca(2+)-containing medium presumably the result of Ca2+ influx. TET has no inhibitory effect on caffeine-induced transient contraction. Radioligand receptor binding study using isolated dog aortic muscle membranes indicated that TET inhibited the binding of 3H-prazosin in a competitive manner, hence showing that TET interacted directly with the alpha 1-adrenoceptors. Thus, TET affected PE-induced aortic contractions by multiple mechanisms, inhibiting interaction of PE with alpha 1-adrenoceptors and interfering with PE-induced responses involving both Ca2+ entry and release.

References

Aug 1, 1988·Canadian Journal of Physiology and Pharmacology·Y Y GuanE E Daniel
Aug 1, 1984·Journal of Molecular and Cellular Cardiology·C Y KwanE E Daniel
Mar 1, 1982·Journal of Natural Products·J W BanningP N Patil

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Citations

Sep 5, 2002·European Journal of Pharmacology·Yvonne SlaterIsabel Bermúdez
Jan 29, 2009·Natural Product Research·Jun ChenZhangqun Ye
Jul 8, 2008·Cell Calcium·Yan Dong ZhouZong Jie Cui
Sep 16, 2020·Pharmacology Research & Perspectives·Paula M Heister, Robin N Poston
Feb 26, 2004·The Journal of Pharmacy and Pharmacology·X-C YuT M Wong
Aug 31, 2010·Journal of Ethnopharmacology·Deepak Kumar SemwalUsha Rawat

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