Tetranuclear ruthenium(II) complexes with oligo-oxyethylene linkers as one- and two-photon luminescent tracking non-viral gene vectors

Dalton Transactions : an International Journal of Inorganic Chemistry
Kangqiang QiuHui Chao

Abstract

To prolong the observation time, increase the penetration depth and decrease self-absorption and phototoxicity, two-photon luminescent vectors have emerged as promising tools for tracking gene delivery in living cells. Herein, we report four new tetranuclear Ru(ii) complexes based on oligo-oxyethylene and polybenzimidazole as one- and two- photon luminescent tracking non-viral gene vectors. In such a molecular design, the oligo-oxyethylene, polybenzimidazole and Ru(ii) polypyridyl complexes were expected to render the vectors with increased cell permeability, biocompatibility, proton buffering capacity and one- and two-photon luminescence. Corresponding DNA interaction studies showed that the ability of the complexes to condense DNA decreased with increasing oligo-oxyethylene lengths. Additionally, all complexes protected DNA. The complexes were investigated as one- and two-photon tracking non-viral gene vectors in living cells and showed proper cellular uptake, good luciferase expression and low cytotoxicity.

References

May 14, 1993·Science·R C Mulligan
Nov 27, 2001·Science·D Ferber
Apr 26, 2003·Science·Radoslav SavicDusica Maysinger
May 2, 2003·Journal of Biomedicine & Biotechnology·Kate L. DishartAndrew H. Baker
Jan 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Indrajit RoyParas N Prasad
Jul 30, 2005·Nature Reviews. Drug Discovery·Daniel W PackPatrick S Stayton
Aug 30, 2008·Nature Methods·Ute Resch-GengerThomas Nann
Dec 5, 2008·Chemical Reviews·Meredith A Mintzer, Eric E Simanek
Apr 2, 2009·Accounts of Chemical Research·Hwan Myung Kim, Bong Rae Cho
Jul 2, 2011·Journal of the American Chemical Society·Chang Su LimBong Rae Cho
Sep 8, 2011·Chemical Communications : Chem Comm·Satish S BhatEvamarie Hey-Hawkins
Dec 14, 2012·Chemical Communications : Chem Comm·Bole YuHui Chao
Jan 25, 2013·Biomaterials·Yoko Endo-TakahashiYukihiko Aramaki
Nov 30, 2013·International Journal of Pharmaceutics·D IbraheemH Fessi
Apr 28, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei QuXian-Zheng Zhang
Feb 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sandy Budi HartonoChengzhong Yu
May 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tianshi FengXuesi Chen
Aug 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ana L Barrán-BerdónEmilio Aicart

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Citations

Nov 20, 2016·Chemistry, an Asian Journal·Satish S BhatMarek Necas
Nov 28, 2017·Chemical Society Reviews·Fergus E PoyntonThorfinnur Gunnlaugsson
Jul 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kangqiang QiuHui Chao
Sep 30, 2017·Journal of Inorganic Biochemistry·Satish S BhatKishore Bhat
May 6, 2017·ACS Applied Materials & Interfaces·Kangqiang QiuHui Chao

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