Abstract
Postoperative radiotherapy is used to prevent local recurrence of head and neck squamous cell carcinoma in patients with positive surgical margins. We sought to determine whether tetranucleotide microsatellite instability could be detected in surgical margins and used to predict local recurrence. We prospectively collected tumor and surgical margin specimens from patients with head and neck squamous cell carcinoma who had undergone surgical resection at Institut Gustave-Roussy during a 1-year period. Margins were considered positive if extensive pathological examination revealed either carcinoma within 5 mm or dysplasia. We tested five tetranucleotide microsatellite markers (UT5085, L17686, D9S753, ACTBP2, and CSF1R) in the tumor specimens and paired surgical margins of the patients whose margins were negative on pathological examination. Pathological examination revealed that among the 76 patients, 22 had positive margins; therefore, these patients were excluded. Of the 54 remaining patients, 26 (48%) had tumors informative for markers UT5085, L17686, or both; the other 3 markers were not informative. Seven (27%) of the 26 informative tumors had the same instability pattern in the surgical margins. At a median follow-up of 26 ...Continue Reading
References
Oct 1, 1990·American Journal of Surgery·T R Loree, E W Strong
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Feb 16, 1995·The New England Journal of Medicine·J A BrennanD Sidransky
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·L MaoD Sidransky
Feb 1, 1994·Nature Genetics·R WoosterO D Wiestler
Jan 1, 1993·International Journal of Radiation Oncology, Biology, Physics·M J ZelefskyE W Strong
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L J PetersR A Frankenthaler
Sep 1, 1996·Nature Medicine·H NawrozD Sidransky
Jan 1, 1997·Human Mutation·N Papadopoulos, A Lindblom
May 26, 1999·Advances in Anatomic Pathology·J G Batsakis
Sep 19, 2000·Genes, Chromosomes & Cancer·I SardiO Gallo
Jan 9, 2001·International Journal of Cancer. Journal International Du Cancer·L XuJ Jen
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M WeijersI van der Waal
May 7, 2002·Nature Reviews. Cancer·David Sidransky
Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Patrick K HaJoseph A Califano
Dec 4, 2002·The Laryngoscope·Cherie-Ann O NathanFred J Stucker
May 29, 2003·British Journal of Cancer·S TemamF Janot
Jun 5, 2003·The Laryngoscope·Keshav T MaggeJonas T Johnson
Citations
May 3, 2007·European Journal of Human Genetics : EJHG·Harlinde De SchutterSandra Nuyts
Dec 2, 2010·Transplantation·Sharon EladReuven Or
Nov 1, 2012·Annals of Surgical Oncology·Richard J ShawJanet M Risk
Apr 3, 2014·British Journal of Cancer·M M C WatsonK Søreide
Dec 2, 2015·Expert Review of Molecular Diagnostics·Steven W MesRuud H Brakenhoff
Aug 12, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xinhong WangXueyi Liang
Mar 2, 2010·Oral Oncology·Boudewijn J M BraakhuisRuud H Brakenhoff
May 12, 2009·Head & Neck·Parul SinhaS Datta Gupta
Jun 23, 2010·International Journal of Cancer. Journal International Du Cancer·A Peggy GravelandBoudewijn J M Braakhuis
Mar 25, 2016·Scientific Reports·Jin-Ching LinShih-An Liu
Nov 23, 2011·Oral Oncology·Ana Carolina de CarvalhoAndré Luiz Vettore
Jun 24, 2011·Oral Oncology·Gordana SupicZvonko Magic
Jul 20, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jin-Ching LinShih-An Liu
Dec 1, 2017·BMC Research Notes·Giorgia CapocasaleGiuseppina Campisi
Jul 3, 2008·British Journal of Cancer·H K TanS Temam
Dec 22, 2005·Blood·Philipp FaberAlexandros Spyridonidis
Sep 18, 2020·Biomarkers in Medicine·Reza RanjbarSomayeh Mohammadpour
Jan 18, 2018·The British Journal of Surgery·S A LiuJ C Lin
Dec 15, 2018·Journal of Cellular Physiology·Amir Torshizi EsfahaniHamid Asadzadeh Aghdaei
Oct 22, 2020·Cancers·Maria CilonaOreste Gallo
Oct 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaohong HuangMax Partridge
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Scott M Lippman, John V Heymach