PMID: 7024547Aug 1, 1981Paper

Tetraploidy in a liveborn infant with spina bifida and other anomalies

Journal of Medical Genetics
D PittJ Rogers

Abstract

Although tetraploidy of human chromosomes (92,XXYY) has been described frequently in abortuses, only one example in a liveborn infant has previously been described. A second malformed infant with a complete tetraploid chromosome complement, who lived for 15 days, is reported. In addition to many of the malformations described in the first case, this infant also had a sacral myelomeningocele and skeletal anomalies. The probable origin of the tetraploidy was a failure of cytoplasmic cleavage at the first mitotic division of the fertilised ovum.

References

Jan 1, 1977·Cytogenetics and Cell Genetics·T Kajii, N Niikawa
Aug 1, 1976·Journal of Medical Genetics·M S GolbusB D Hall
Feb 12, 1976·The New England Journal of Medicine·L B HolmesL Atkins

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Citations

Jan 1, 1982·Human Genetics·D M SheppardS Povey
Oct 1, 1992·Journal of Assisted Reproduction and Genetics·K A GinsburgM P Johnson
Feb 1, 1992·Journal of Assisted Reproduction and Genetics·L E ShieldsC M Moore
Apr 2, 2003·Annales de génétique·Luís AlonsoDecio Brunoni
Mar 21, 2002·Clinical Genetics·M Guc-ScekicM Djordjevic
Mar 23, 2010·Clinical Dysmorphology·Irina StefanovaGabriele Gillessen-Kaesbach
Dec 1, 1990·Journal of Medical Genetics·I López PajaresM Martin
Jan 10, 2008·Taiwanese Journal of Obstetrics & Gynecology·Chih-Ping Chen
Sep 1, 1984·American Journal of Medical Genetics·P R ScarbroughB W Althaus
Feb 1, 1993·American Journal of Medical Genetics·S J CoeD Kramer
Mar 1, 1988·American Journal of Medical Genetics·H ShionoK Kikuchi
Oct 1, 1988·American Journal of Medical Genetics·C Z Lafer, R L Neu
Sep 1, 1985·British Journal of Obstetrics and Gynaecology·A T TharapelR M Bannerman
Aug 1, 1988·American Journal of Medical Genetics·G N WilsonP Kaplan
Mar 11, 2015·Scientific Reports·Takuro HoriiIzuho Hatada
Dec 1, 1982·Clinical Genetics·H VeenemaJ P Geraedts
Feb 1, 1985·Clinical Genetics·E QuirozF Salamanca

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