Tetrapod Polymersomes.

Journal of the American Chemical Society
Jiangang Xiao, Jianzhong Du

Abstract

Hollow nanoparticles such as polymersomes have promising potentials in many fields. However, the design and construction of higher-order polymersomes with precisely controlled spatial compartments is still very challenging. Herein, we report a unique tetrapod polymersome that is assembled by the controlled fusion of four traditional spherical polymersomes. This original species was prepared from poly(ethylene oxide)113-b-poly[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl methacrylate61-stat-2-(diethylamino)ethyl methacrylate23] [PEO113-b-P(TBA61-stat-DEA23)] in DMF/water at lower water content (Cw), where PEO acts as corona forming block. To unravel the secret behind the tetrapod polymersomes, a series of block copolymers with various comonomer types and degrees of polymerization were synthesized and self-assembled. PEO113-b-PTBA80 self-assembles into spherical micelles in DMF/water, and the subsequent evolution into tripod and multipod micelles and finally micelle clusters was achieved by increasing Cw. This suggests that relatively rigid TBA is a "pro-fusion" component that facilitates particle-particle fusion due to its providential hydrophobicity and chain mobility. When one-fourth of TBA of PEO113-b-PTBA80 is subst...Continue Reading

References

Mar 30, 2002·Science·George M Whitesides, Bartosz Grzybowski
Aug 10, 2002·Science·Dennis E Discher, Adi Eisenberg
May 24, 2003·Nature Materials·Liberato MannaA Paul Alivisatos
Sep 15, 2005·Journal of the American Chemical Society·Jianzhong Du, Steven P Armes
Dec 22, 2005·Journal of the American Chemical Society·Jianzhong DuSteven P Armes
Jan 19, 2006·Journal of the American Chemical Society·Luigi CarboneLiberato Manna
Jun 4, 2008·Physical Review Letters·Miho YanagisawaTakashi Taniguchi
Aug 20, 2010·Journal of the American Chemical Society·Kyoung Taek KimJan C M van Hest
Jan 21, 2011·Nature·Qian ChenSteve Granick
Mar 20, 2012·Nature Communications·André H GröschelAxel H E Müller
Mar 23, 2012·Nature Chemistry·Daniela A WilsonJan C M van Hest
Jul 11, 2012·Chemical Society Reviews·Yiyong Mai, Adi Eisenberg
Aug 4, 2012·Science·Paul A RuparIan Manners
Feb 26, 2013·Nano Letters·Andrew P MagyarEvelyn L Hu
Oct 26, 2013·Journal of the American Chemical Society·Matthijs C M van OersJan C M van Hest
Feb 16, 2016·Journal of the American Chemical Society·Xiaoyu LiIan Manners
Jun 30, 2016·Nature Communications·Tina I LöblingAxel H E Müller
Aug 24, 2016·Journal of the American Chemical Society·Xiaoyu LiIan Manners
Feb 12, 2017·ACS Nano·Yingfeng TuDaniela A Wilson
May 17, 2017·Journal of the American Chemical Society·Yufen XiaoJianzhong Du
Jul 28, 2018·Nano Letters·Fangyingkai WangJianzhong Du
Oct 31, 2018·Nature Nanotechnology·Ji WangXi Xie
Apr 19, 2019·Chemical Science·Chin Ken WongPall Thordarson
Aug 23, 2019·Chemistry, an Asian Journal·Rémi MérindolSerge Ravaine
Sep 29, 2019·Nature Communications·Tiancong ZhaoDongyuan Zhao

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Citations

Nov 20, 2020·Macromolecular Rapid Communications·Jinkang DouDaoyong Chen
Nov 3, 2020·International Journal of Pharmaceutics·Mahsa ZahiriMona Alibolandi
Aug 15, 2021·Journal of Colloid and Interface Science·Chendan LiJunyou Wang
Oct 30, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Zhengping TanJiangping Xu

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