Tetraspanin CD81 promotes tumor growth and metastasis by modulating the functions of T regulatory and myeloid-derived suppressor cells

Cancer Research
Felipe Vences-CatalanShoshana Levy

Abstract

Tumor cells counteract innate and adaptive antitumor immune responses by recruiting regulatory T cells (Treg) and innate myeloid-derived suppressor cells (MDSC), which facilitate immune escape and metastatic dissemination. Here we report a role in these recruitment processes for CD81, a member of the tetraspanin family of proteins that have been implicated previously in cancer progression. We found that genetic deficiency in CD81 reduced tumor growth and metastasis in two genetic mouse backgrounds and multiple tumor models. Mechanistic investigations revealed that CD81 was not required for normal development of Treg and MDSC but was essential for immunosuppressive functions. Notably, adoptive transfer of wild-type Treg into CD81-deficient mice was sufficient to promote tumor growth and metastasis. Our findings suggested that CD81 modulates adaptive and innate immune responses, warranting further investigation of CD81 in immunomodulation in cancer and its progression.

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Citations

Jul 29, 2016·Oncoimmunology·Felipe Vences-CatalánShoshana Levy
Dec 30, 2017·International Journal of Molecular Sciences·Hisatsugu Goto, Yasuhiko Nishioka
Apr 15, 2017·Biochemical Society Transactions·Felipe Vences-CatalánShoshana Levy
Apr 15, 2017·Biochemical Society Transactions·Ibrahim H YaseenLynda J Partridge
Jul 1, 2017·Journal of Cellular Physiology·Elham SafarzadehBehzad Baradaran
May 28, 2019·The Journal of Experimental Medicine·Felipe Vences-CatalánShoshana Levy
Jun 7, 2019·The Journal of Experimental Medicine·Ralf Küppers
Apr 28, 2016·Oncotarget·Rubén Fernández-RodríguezJuan Carlos Rodríguez-Manzaneque
Aug 28, 2016·Oncotarget·Thomas BoyerMeyling Cheok
Sep 9, 2019·Cellular Oncology (Dordrecht)·Naoki MizoshiriToshikazu Kubo
Jun 28, 2018·Frontiers in Immunology·Felipe Vences-Catalán, Shoshana Levy
Jun 20, 2017·Integrative Cancer Therapies·Anita Thyagarajan, Ravi P Sahu
Oct 1, 2019·Disease Markers·Felix BremmerFriedemann Honecker
Jun 14, 2018·Frontiers in Immunology·Fleur Schaper, Annemiek B van Spriel
Jan 6, 2019·Science China. Life Sciences·Shanshan YanBing Sun
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Mar 7, 2021·International Journal of Molecular Sciences·Petra M WiseDaniela Grimm
Mar 16, 2021·Critical Reviews in Oncology/hematology·RamaRao MallaGanji Purnachandra Nagaraju
Mar 19, 2021·British Journal of Cancer·Matthew DeyellAshley M Laughney
Jun 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Felipe Vences-CatalánShoshana Levy
Nov 4, 2021·Breast Cancer Research and Treatment·Brooke E WilsonDavid W Cescon

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