Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity

Cancer Metastasis Reviews
Jin FengXin A Zhang

Abstract

Tetraspanin CD82 suppresses the progression and metastasis of a wide range of solid malignant tumors. However, its roles in tumorigenesis and hematopoietic malignancy remain unclear. Ubiquitously expressed CD82 restrains cell migration and cell invasion by modulating both cell-matrix and cell-cell adhesiveness and confining outside-in pro-motility signaling. This restraint at least contributes to, if not determines, the metastasis-suppressive activity and, also likely, the physiological functions of CD82. As a modulator of cell membrane heterogeneity, CD82 alters microdomains, trafficking, and topography of the membrane by changing the membrane molecular landscape. The functional activities of membrane molecules and the cytoskeletal interaction of the cell membrane are subsequently altered, followed by changes in cellular functions. Given its pathological and physiological importance, CD82 is a promising candidate for clinically predicting and blocking tumor progression and metastasis and also an emerging model protein for mechanistically understanding cell membrane organization and heterogeneity.

References

Sep 16, 1998·Clinical and Experimental Immunology·M FerrerP A Lazo
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Apr 23, 2003·The Journal of Molecular Diagnostics : JMD·Chris CheadleKevin G Becker
Aug 26, 2003·European Journal of Immunology·Stéphanie CharrinEric Rubinstein
Oct 25, 2003·Journal of Cell Science·Elena OdintsovaFedor Berditchevski
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
Dec 14, 2004·Journal of Cancer Research and Clinical Oncology·Andreas M StarkJanka Held-Feindt
Dec 25, 2004·The International Journal of Biochemistry & Cell Biology·Paul JacksonPamela J Russell
Jan 29, 2005·The Journal of Biological Chemistry·Rosemary BassVincent Ellis
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Huayi HuangJoseph Geradts
Nov 2, 2005·Cancer Letters·Wei M Liu, Xin A Zhang
Nov 8, 2005·Trends in Molecular Medicine·Hélène Tonoli, J Carl Barrett
Feb 21, 2006·Biochemical and Biophysical Research Communications·Bo Keun JeeYoung Lim
Jul 25, 2006·Nature Medicine·Sucharita BandyopadhyayKounosuke Watabe
Dec 16, 2006·Nucleic Acids Research·David L WheelerEugene Yaschenko
Jan 11, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tali TohamiMichael Lishner
Mar 30, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xing AiTaoping Shi
Jun 15, 2007·Biochemical and Biophysical Research Communications·Bo Keun JeeYang-Hyeok Jo
Jul 11, 2007·International Journal of Cancer. Journal International Du Cancer·Miho TakahashiKanemitsu Shirasuna
Nov 22, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Jian-Min YangZai-Yuan Ye
Nov 27, 2007·Nature Medicine·Yien Che TsaiAllan M Weissman
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Adriane Regina TodeschiniSen-itiroh Hakomori
Feb 21, 2008·World Journal of Gastroenterology : WJG·Jian-Hua XuMin-Pei Liu
Jul 16, 2008·Science in China. Series C, Life Sciences·Zhenbin MuXiaozhong Guo
Aug 21, 2008·International Journal of Cancer. Journal International Du Cancer·Matthias ChristgenUlrich Lehmann
Sep 23, 2008·Cellular Signalling·Michael LishnerLiat Drucker
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cécile ArduiseFrançois Le Naour
Dec 17, 2008·Nature Reviews. Cancer·Margot Zöller
Dec 26, 2008·The New England Journal of Medicine·Anne C Chiang, Joan Massagué

❮ Previous
Next ❯

Citations

Apr 15, 2017·Biochemical Society Transactions·Ibrahim H YaseenLynda J Partridge
Jul 8, 2018·Annals of the Rheumatic Diseases·Elena NeumannUlf Mueller-Ladner
Dec 29, 2016·Oncotarget·Jiexin ZhangXiao Han
Mar 31, 2017·Oncology Letters·Hui YanPeiquan Zhao
Feb 24, 2020·GeroScience·Yin ZhaoXin A Zhang
Jun 28, 2018·Frontiers in Immunology·Felipe Vences-Catalán, Shoshana Levy
Aug 28, 2021·International Journal of Molecular Sciences·Laurent FernandezPierre-Emmanuel Milhiet
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianwen LongXuwen Yin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.