Tetratricopeptide-motif-mediated interaction of FANCG with recombination proteins XRCC3 and BRCA2

DNA Repair
S HussainNigel J Jones

Abstract

Fanconi anaemia is an inherited chromosomal instability disorder characterised by cellular sensitivity to DNA interstrand crosslinkers, bone-marrow failure and a high risk of cancer. Eleven FA genes have been identified, one of which, FANCD1, is the breast cancer susceptibility gene BRCA2. At least eight FA proteins form a nuclear core complex required for monoubiquitination of FANCD2. The BRCA2/FANCD1 protein is connected to the FA pathway by interactions with the FANCG and FANCD2 proteins, both of which co-localise with the RAD51 recombinase, which is regulated by BRCA2. These connections raise the question of whether any of the FANC proteins of the core complex might also participate in other complexes involved in homologous recombination repair. We therefore tested known FA proteins for direct interaction with RAD51 and its paralogs XRCC2 and XRCC3. FANCG was found to interact with XRCC3, and this interaction was disrupted by the FA-G patient derived mutation L71P. FANCG was co-immunoprecipitated with both XRCC3 and BRCA2 from extracts of human and hamster cells. The FANCG-XRCC3 and FANCG-BRCA2 interactions did not require the presence of other FA proteins from the core complex, suggesting that FANCG also participates in a ...Continue Reading

References

Oct 23, 1997·American Journal of Human Genetics·H JoenjeF Arwert
Aug 15, 1998·The Journal of Biological Chemistry·D K BishopA Shinohara
Oct 17, 1998·Molecular and Cellular Biology·Y Yamaguchi-IwaiS Takeda
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·Q WaisfiszH Joenje
Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L Blatch, M Lässle
Feb 1, 2000·Biochemical and Biophysical Research Communications·P A HuberC G Mathew
Mar 21, 2000·Genesis : the Journal of Genetics and Development·D L Pittman, J C Schimenti
Aug 1, 2000·Human Molecular Genetics·N C ChengF Arwert
Nov 7, 2000·Human Molecular Genetics·J P de WinterH Joenje
Mar 10, 2001·Molecular Cell·I Garcia-HigueraA D D'Andrea
Jul 5, 2001·Experimental Hematology·K NakanishiA D D'Andrea
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S L GasiorD K Bishop
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J Y MassonS C West
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A Kuzminov
Jan 5, 2002·Molecular and Cellular Biology·Maria Kraakman-van der ZwetMalgorzata Z Zdzienicka
Mar 22, 2002·The Lancet Oncology·P J McHughJ A Hartley
Mar 29, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Henri J van de VrugtFré Arwert
May 10, 2002·Nucleic Acids Research·Barbara C GodthelpMassgorzata Z Zdzienicka
Jun 18, 2002·Science·Niall G HowlettAlan D D'Andrea
Jul 16, 2002·Carcinogenesis·Martin DigweedKarl Sperling
Oct 2, 2002·Human Molecular Genetics·Pietro PichierriFilippo Rosselli
Nov 21, 2002·Nature·Luca PellegriniAshok R Venkitaraman
Apr 30, 2003·Molecular Cell·Judith Henry-MowattKeith W Caldecott
May 2, 2003·Molecular and Cellular Biology·Amom Ruhikanta MeeteiWeidong Wang
Jun 5, 2003·Nature Reviews. Molecular Cell Biology·Stephen C West
Aug 2, 2003·Genes & Development·Scott HoughtalingMarkus Grompe
Aug 14, 2003·Human Molecular Genetics·Shobbir HussainChristopher G Mathew
Sep 16, 2003·Nature Genetics·Amom Ruhikanta MeeteiWeidong Wang
Oct 29, 2003·Molecular Cell·David S YuAshok R Venkitaraman

❮ Previous
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Citations

Sep 26, 2006·Oncogene·C G Mathew
Aug 26, 2011·Human Molecular Genetics·Stacy A WilliamsGary M Kupfer
Oct 7, 2009·Molecular and Cellular Biology·Nikhil BhagwatPeter J McHugh
Sep 25, 2007·Annual Review of Genomics and Human Genetics·Peter J McKinnon, Keith W Caldecott
Jun 8, 2012·Anemia·Charlotte Hodson, Helen Walden
Oct 3, 2008·American Journal of Veterinary Research·Yasunaga YoshikawaToshihiko Iwanaga
Apr 30, 2014·Annual Review of Biophysics·Helen Walden, Andrew J Deans
Jul 7, 2009·Mutation Research·Takeo OhnishiAkihisa Takahashi
Jul 24, 2007·Cancer Letters·Alex Lyakhovich, Jordi Surralles
Jun 23, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Stacie StoneMaureen E Hoatlin
Jul 4, 2006·DNA Repair·John M HinzLarry H Thompson
Jul 25, 2006·Experimental Cell Research·Kanchan D Mirchandani, Alan D D'Andrea
Mar 11, 2015·Journal of Cellular Biochemistry·Muriel W Lambert
Mar 21, 2018·Experimental Biology and Medicine·Muriel W Lambert
Nov 15, 2018·International Journal of Cancer. Journal International Du Cancer·Stephanie SchubertDoris Steinemann
Oct 5, 2019·Experimental Biology and Medicine·Muriel W Lambert
Sep 26, 2009·Acta Biochimica Et Biophysica Sinica·Jian DuJilong Shen
Dec 24, 2008·Biochemistry·Joel A LeffertsMuriel W Lambert

❮ Previous
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