PMID: 6160139Sep 1, 1980Paper

Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity

The Journal of Antibiotics
T TamaokiF Tomita

Abstract

Novel antitumor antibiotics, tetrocarcin complex composed of three components (A, B and C) were isolated from the culture broth of Micromonospora chalcea KY11091 through various procedures. Tetrocarcins showed marked activity against experimental tumors such as mouse sarcoma 180 and mouse leukemia P388. Multiple injections showed better therapeutic effect against tumors. Mode of action of tetrocarcin A against Bacillus subtilis was found to be through the inhibition of RNA synthesis.

Citations

Jul 22, 2016·Wiley Interdisciplinary Reviews. RNA·Kerstin A EffenbergerMelissa S Jurica
Jun 27, 2014·Natural Product Reports·Laura ViewegRoderich D Süssmuth
Jul 8, 2020·Organic & Biomolecular Chemistry·Sudip Mandal, Barla Thirupathi
Dec 4, 2010·Natural Product Reports·Ronald ParryJim Spain
Nov 14, 2013·The Journal of Antibiotics·Zhenjian LinEric W Schmidt
Aug 11, 2015·Organic Chemistry Frontiers : an International Journal of Organic Chemistry·Michelle H LacoskeEmmanuel A Theodorakis
Jan 26, 2013·Chemical Society Reviews·Chia-I LinHung-wen Liu
Mar 13, 2021·Natural Product Reports·Xuhua Mo, Tobias A M Gulder
Aug 28, 1999·Journal of Medicinal Chemistry·W A CraigoE B Skibo
May 24, 2012·Journal of Natural Products·Carlo MazzettiStefano Donadio
Apr 27, 2017·Chemical Reviews·Byung-Sun JeonHung-Wen Liu
Dec 2, 2014·Journal of Natural Products·Michelle H Lacoske, Emmanuel A Theodorakis
Dec 15, 2005·Chemical Reviews·Ken-Ichi TakaoKin-ichi Tadano

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