PMID: 6023268May 19, 1967Paper

Tetrodotoxin derivatives: chemical structure and blockage of nerve membrane conductance

Science
T NarahashiR N Poston

Abstract

The nerve-impuilse-blocking actions of derivatives of tetrodotoxin have been tested on lobster and squid axons. The block produced by deoxytetrodotoxin was similar to that produced by tetrodotoxin and was probably caused by tetrodotoxin contamination. Tetrodaminotoxin and anhydrotetrodotoxin also produced a similar block but at such high concentrations that tetrodotoxin contamination cannot be ruled out. The hydroxyl group of C(4) and the hemilactal oxygen links play an important role for the nerve-blocking action.

References

Sep 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·I TasakiA Watanabe
Nov 1, 1964·Chemical & Pharmaceutical Bulletin·K TsudaK Sakai
Sep 1, 1966·The American Journal of Physiology·I TasakiA Watanabe
May 1, 1966·The Journal of General Physiology·M TakataF A Fuhrman
May 1, 1967·The Journal of General Physiology·J W MooreT Narahashi
May 1, 1967·The Journal of General Physiology·T NarahashiJ W Moore
May 1, 1964·The Journal of General Physiology·T NARAHASHIW R SCOTT

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Citations

Jul 1, 1968·Bulletin of Environmental Contamination and Toxicology·F Matsumura, C M Wang
Aug 11, 1975·The Journal of Membrane Biology·Y SoedaT Narahashi
Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·C H Levenson, A M Woodhull
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·C Y Kao, T Yasumoto
Mar 17, 1999·Toxicon : Official Journal of the International Society on Toxinology·K KawatsuY Hamano
Apr 1, 1970·The Journal of General Physiology·R VillegasG Camejo
Mar 14, 2012·Biological Procedures Online·Amber N StokesSusannah S French
Jan 28, 2014·PloS One·Michael EdgehouseEdmund D Brodie
Apr 15, 2010·Marine Drugs·Harry A Fozzard, Gregory M Lipkind
Jun 1, 1997·Japanese Journal of Medical Science & Biology·K KawatsuT Shibata
Apr 1, 1972·Journal of Neurochemistry·R J Bull, A J Trevor
Dec 1, 1973·Experientia·E Zlotkin
Oct 29, 2014·The Journal of General Physiology·Yu Zhou, Christopher J Lingle
Dec 29, 2009·Toxicon : Official Journal of the International Society on Toxinology·Stacey M Etheridge
Jan 1, 1970·Progress in Biophysics and Molecular Biology·B Hille
Mar 16, 2007·Toxicon : Official Journal of the International Society on Toxinology·Jeen Hee LeeShugo Watabe
Jul 1, 1987·Clinics in Dermatology·J A Williamson
Jul 18, 2015·Archives of Insect Biochemistry and Physiology·Lacey J Jenson, Jeffrey R Bloomquist
Jan 14, 2003·Biophysical Journal·Gaurav ChoudharySamuel C Dudley
Mar 12, 1968·Biochemical and Biophysical Research Communications·E W Hopkins, E J Herbst
Feb 27, 1973·Biochimica Et Biophysica Acta·F V BarnolaG Camejo
Jan 1, 1986·Annals of the New York Academy of Sciences·C Y Kao
Jan 1, 1986·Annals of the New York Academy of Sciences·H S Mosher
Feb 9, 1976·Biochemical and Biophysical Research Communications·V E GhazarossianF M Strong
Aug 28, 2014·Toxicon : Official Journal of the International Society on Toxinology·Brian G GallEdmund D Brodie
Jan 6, 2015·Toxicon : Official Journal of the International Society on Toxinology·Lauren SalvittiS Craig Cary
Dec 1, 2011·Toxicon : Official Journal of the International Society on Toxinology·Monrat ChulanetraWanpen Chaicumpa
Apr 5, 2011·Toxicon : Official Journal of the International Society on Toxinology·Brian G GallEdmund D Brodie
Aug 8, 2012·Toxicon : Official Journal of the International Society on Toxinology·Brian G GallEdmund D Brodie
Nov 12, 2013·Toxicon : Official Journal of the International Society on Toxinology·Holger FeroudjShugo Watabe
Mar 14, 2008·PLoS Biology·Charles T HanifinEdmund D Brodie
Dec 16, 1975·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R Y TsienJ K Sanders
Jan 1, 1969·Journal of Neurobiology·T NarahashiR N Poston
Jan 1, 1969·Pflügers Archiv : European journal of physiology·E Koppenhöfer, W Vogel

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