Tetrodotoxin in Asian newts (Salamandridae)

Toxicon : Official Journal of the International Society on Toxinology
Mari Yotsu-YamashitaDietrich Mebs

Abstract

Tetrodotoxin (TTX) and its analogues occur in a wide range of marine animals but also in terrestrial vertebrates such as frogs, toads and newts. Despite numerous studies on TTX in New World newts (Notophthalmus viridescens, Taricha spp.), few data only exist for Asian newts. Methanolic extracts of newts from China (Cynops orientalis, Pachytriton labiatus, Paramesotriton chinensis), Vietnam (Paramesotriton deloustali, P. guangxiensis), and Laos (Laotriton laoensis) were analyzed by liquid-chromatography-fluorescent detection (LC-FLD) and mass-spectrometry (LC-MS). In all species, variable amounts of TTX were detected, in most specimens also TTX-analogues like 6-epiTTX, in C. orientalis 11-oxoTTX, confirming the presence of these toxins in modern Asian newts.

Citations

Mar 6, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Eugenia SanchezSebastian Steinfartz
Oct 7, 2020·Natural Product Reports·Roberto G S BerlinckIgor D Jurberg
May 3, 2021·Toxicon : Official Journal of the International Society on Toxinology·Dietrich Mebs, Mari Yotsu-Yamashita

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