PMID: 8959164Dec 1, 1996Paper

Tetrodotoxin infusion: nonventilatory effects and role in toxicity models

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
C F MackenzieS G Park

Abstract

To determine the cardiovascular, autonomic, and neuromuscular effects of an IV infusion of tetrodotoxin (TTX) when ventilation is supported. TTX was infused in 18 anesthetized beagles during conventional mechanical ventilation. TTX infusion continued at a rate of 9.3 micrograms/kg/hr until apnea occurred with 1 minute of ventilator disconnection. Measurements included intravascular pressures, heart rate (HR), cardiac output, blood gases, displacements of the rib cage and abdomen, O2 delivery, and responses to train-of-four and tetanic peripheral nerve stimulation. Results are expressed as mean +/- SD. During TTX infusion, all the dogs had discoordinate movements of the rib cage, abdomen, and limbs. Vomiting, urination, defecation, and increased salivation occurred. Nicotinic and muscarinic effects, neuromuscular blockade, and cardiovascular depression were produced by TTX. Apnea occurred in 72.0 +/- 17.0 minutes when a total of 119.0 +/- 17.4 micrograms of TTX was infused. At apnea, decreases in arterial pressure, cardiac index, HR, O2 delivery, and systemic vascular resistance occurred, while pulmonary artery pressure and pulmonary vascular resistance increased. Loss of response to tetanic stimulation was closely correlated wi...Continue Reading

References

Jul 11, 1975·Science·Y H KimF A Mosher
Aug 1, 1992·Anesthesia and Analgesia·R J WatsonG M Barnas
Nov 1, 1991·Annals of Emergency Medicine·J E MendhamM K Ewing
Dec 1, 1990·Anesthesia and Analgesia·C F MackenzieS Nesbitt
Jan 1, 1988·Annals of the New York Academy of Sciences·B K Siesjö
May 1, 1989·Neurology·K OdaH Shibasaki
Jan 23, 1988·Lancet·A R Mills, R Passmore
Jan 1, 1987·Central Nervous System Trauma : Journal of the American Paralysis Association·W Young
Sep 1, 1986·Annals of Emergency Medicine·J K Sims, D C Ostman
Jun 1, 1971·The Japanese Journal of Physiology·F Ito
Mar 24, 1973·The Medical Journal of Australia·T A TordaD B Ulyatt
Jul 1, 1967·Toxicon : Official Journal of the International Society on Toxinology·C Y Kao, F A Fuhrman
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall
Jun 1, 1981·Papua and New Guinea Medical Journal·J D VinceL O Larsson
Mar 1, 1981·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G B Koelle
Jul 17, 1981·JAMA : the Journal of the American Medical Association·S G Bradley, L J Klika

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.