PMID: 698823Oct 6, 1978Paper

Tetrodotoxin sensitivity and Ca component of action potentials of mouse dorsal root ganglion cells cultured in vitro

Brain Research
Y MatsudaT Yonezawa

Abstract

In the mouse dorsal root ganglia cultured in vitro, neurons were classified into 3 groups according to the responses of their action potentials to tetrodotoxin (TTX) and removal of Na ions from bathing medium: (1) the neurons whose action potentials were not affected by TTX by TTX (10(-6) - 10 (-5)g/ml) and which generated Ca-dependent regenerative responses under Na-free condition, (2) the neurons whose spike potentials were resistant to TTX but failed to survive in Na-free saline and (3) the neurons whose action potentials were suppressed by TTX(10(-8)g/ml) as well as Na removal. The mean duration of spike and after-hyperpolarization was longest in the first group of the neurons and shortest in the third, probably reflecting the difference in the contribution of Ca currents to action potentials. The unresponsiveness of the neurons to TTX was shown to be due to the insensitivity of Na as well as Ca components of action potentials to the toxin. It was discussed that the occurrence of TTX-resistant action potentials to the toxin. It was discussed that the occurrence of TTX-resistant action might be related to the neuronal development.

References

May 1, 1977·The Journal of Physiology·M A Dichter, G D Fischbach
Mar 1, 1975·The Journal of Physiology·S I MiyazakiS Sasaki
Dec 1, 1975·Journal of Cellular Physiology·M Kano
Feb 6, 1976·Brain Research·A L Kleinhaus, J W Prichard
May 14, 1976·Brain Research·N C Spitzer, P I Baccaglini
Oct 1, 1972·The Journal of General Physiology·N Sperelakis, K Shigenobu
May 1, 1971·Acta Physiologica Scandinavica·P Redfern, S Thesleff
Jan 1, 1973·Progress in Biophysics and Molecular Biology·H Reuter
Jul 1, 1974·The Journal of Physiology·D ColquhounJ M Ritchie
Apr 1, 1974·The Journal of Physiology·S I MiyazakiK Tsuda
Nov 1, 1971·Acta Physiologica Scandinavica·J B Harris, S Thesleff
Dec 1, 1968·The Journal of Physiology·D Geduldig, D Junge
Mar 1, 1966·The Journal of General Physiology·S Hagiwara, S Nakajima
Mar 25, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·E R PETERSONM R MURRAY

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Citations

Aug 1, 1982·Pflügers Archiv : European journal of physiology·H Ito
Jan 1, 1983·The Journal of Membrane Biology·M Kameyama
Jun 1, 1994·Cellular and Molecular Neurobiology·S Yoshida
Jan 17, 1992·Brain Research. Developmental Brain Research·N Ogata, H Tatebayashi
Nov 4, 1981·Neuroscience Letters·J Fukuda, K Yamaguchi
Jan 30, 1986·Neuroscience Letters·R D RoseL M Mendell
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Jan 1, 1980·Neuroscience·P G Kostyuk
Apr 8, 1998·Journal of Neuroscience Methods·J M ZhangR H LaMotte
Feb 13, 2001·Brain Research Bulletin·N C SpitzerN J Lautermilch
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y Berwald-NetterF Couraud
Jan 1, 1992·The European Journal of Neuroscience·Enzo WankeArnaldo Ferroni

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