PMID: 7076564Feb 1, 1982Paper

Tetronomycin, a novel polyether of unusual structure

The Journal of Antibiotics
C Keller-JuslénA von Wartburg

Abstract

Tetronomycin, C34H50O8, isolated from a strain of Streptomyces sp. nov. represents a novel polycyclic ionophore polyether. The crystal structure and absolute configuration were established by X-ray analysis of the mono-O-acetyltetronomycin silver salt. Tetronomycin is the first metabolic polyether which contains a tetronic acid moiety instead of the essential carboxylic acid function. A trisubstituted cyclohexane ring and an interesting molecular conformation of the silver salt represent additional unique structural features. Extensive NMR-studies enabled the assignment of chemical shifts and the correlation of the proton and carbon signals. Tetronomycin exhibits activity against Gram-positive bacteria.

Citations

Jun 27, 2014·Natural Product Reports·Laura ViewegRoderich D Süssmuth
Feb 18, 2016·Natural Product Reports·Mehdi Zaghouani, Bastien Nay
Oct 13, 2018·Natural Product Reports·Akimasa Miyanaga
Apr 12, 2008·Chembiochem : a European Journal of Chemical Biology·Yuliya DemydchukPeter F Leadlay
Feb 16, 2010·Applied and Environmental Microbiology·Erin A GontangPaul R Jensen
Nov 30, 2007·Chembiochem : a European Journal of Chemical Biology·Yuhui SunPeter F Leadlay
Aug 10, 2006·Chembiochem : a European Journal of Chemical Biology·Barbara M HarveyJonathan B Spencer
May 4, 2016·Journal of Bacteriology·Tomas Gverzdys, Justin R Nodwell
Nov 4, 2009·The Journal of Organic Chemistry·MinJin KangMichael D Burkart

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