TEX264 is a major receptor for mammalian reticulophagy

Autophagy
Elizabeth Delorme-AxfordDaniel J Klionsky

Abstract

The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autophagy machinery. Recently, 2 groups (the laboratories of Noboru Mizushima and Wade Harper) independently identified the previously uncharacterized protein TEX264 (testis expressed gene 264) as a major receptor for selective reticulophagy in mammalian cells. Here we highlight and integrate the major findings of their recent work. Abbreviations: AIM: Atg8-interacting motif; AP-MS: affinity purification-mass spectrometry; ATL3: atlastin GTPase 3; Baf A1: bafilomycin A1; CCPG1: cell cycle progression 1; CRISPR: clustered regularly interspaced short palindromic repeats; GABARAP: gamma-aminobutyric acid receptor associated protein; GFP: green fluorescent protein; GyrI: gyrase inhibitor; IDR: intrinsically disordered region; IP: immunoprecipitation; KO: knockout; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MEF: mouse embryonic fibroblast; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; RB1CC1/FIP200: RB1-inducible coiled-coi...Continue Reading

References

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Citations

Oct 4, 2019·Journal of Cellular Physiology·Milad AshrafizadehSaeed Samarghandian
Mar 18, 2021·Autophagy·John FieldenKristijan Ramadan
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Ming YangLin Sun

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Methods Mentioned

BETA
co-IPs
fluorescence microscopy

Software Mentioned

PSIPRED
Phyre2

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