Texture analysis of speckle in optical coherence tomography images of tissue phantoms

Physics in Medicine and Biology
Kirk W GossageJennifer K Barton

Abstract

Optical coherence tomography (OCT) is an imaging modality capable of acquiring cross-sectional images of tissue using back-reflected light. Conventional OCT images have a resolution of 10-15 microm, and are thus best suited for visualizing tissue layers and structures. OCT images of collagen (with and without endothelial cells) have no resolvable features and may appear to simply show an exponential decrease in intensity with depth. However, examination of these images reveals that they display a characteristic repetitive structure due to speckle. The purpose of this study is to evaluate the application of statistical and spectral texture analysis techniques for differentiating living and non-living tissue phantoms containing various sizes and distributions of scatterers based on speckle content in OCT images. Statistically significant differences between texture parameters and excellent classification rates were obtained when comparing various endothelial cell concentrations ranging from 0 cells/ml to 25 million cells/ml. Statistically significant results and excellent classification rates were also obtained using various sizes of microspheres with concentrations ranging from 0 microspheres/ml to 500 million microspheres/ml. T...Continue Reading

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Citations

Oct 22, 2008·Lasers in Medical Science·Florian Bazant-Hegemark, Nicholas Stone
Nov 15, 2013·Biomedical Engineering Online·Robert KoprowskiEdward Wylegala
Oct 20, 2010·Biomedical Engineering Online·Sami J SavioHannu J Eskola
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Aug 26, 2016·The Laryngoscope·Olubunmi Ajose-PopoolaBrian J F Wong
Dec 22, 2017·Scientific Reports·Saba AdabiMohammadreza Nasiriavanaki
Jan 26, 2018·Journal of Biomedical Optics·Saba AdabiMohammadreza Nasiriavanaki
Dec 5, 2018·Physics in Medicine and Biology·Travis W SawyerJennifer K Barton
Jul 26, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giulio Guagliumi, Vasile Sirbu
Jan 25, 2011·Biomedical Optics Express·Patrick M Pilarski, Christopher J Backhouse
Sep 11, 2012·Journal of Biophotonics·Yu-Sheng LinChien-Cheng Chang
Apr 12, 2011·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Peng LeeXianling Zhang
Nov 26, 2015·Biomedical Optics Express·Yuewen WangXuan Liu
Mar 5, 2013·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Xuan LiuJin U Kang
Dec 27, 2016·Biomedical Optics Express·Sreyankar NandyQuing Zhu
Jun 19, 2008·Physics in Medicine and Biology·Charles-Etienne BisaillonJean-Pierre Monchalin
May 31, 2021·International Journal of Computer Assisted Radiology and Surgery·Jens MöllerDorothea Miller

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