Texture analysis using proton density and T2 relaxation in patients with histological usual interstitial pneumonia (UIP) or nonspecific interstitial pneumonia (NSIP)

PloS One
Maria T A BuzanJulien Dinkel

Abstract

The purpose of our study was to assess proton density (PD) and T2 relaxation time of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) and to evaluate their utility in differentiating the two patterns. Furthermore, we aim to investigate whether these two parameters could help differentiate active-inflammatory and stable-fibrotic lesions in NSIP. 32 patients (mean age: 69 years; M:F, 1:1) with pathologically proven disease (UIP:NSIP, 1:1), underwent thoracic thin-section multislice CT scan and 1.5T MRI. A total of 437 regions-of-interest (ROIs) were classified at CT as advanced, moderate or mild alterations. Based on multi-echo single-shot TSE sequence acquired at five echo times, with breath-holding at end-expiration and ECG-triggering, entire lung T2 and PD maps were generated from each subject. The T2 relaxation time and the respective signal intensity were quantified by performing a ROI measurement on the T2 and PD maps in the corresponding CT selected areas of the lung. UIP and NSIP regional patterns could not be differentiated by T2 relaxation times or PD values alone. Overall, a strong positive correlation was found between T2 relaxation and PD in NSIP, r = 0.64, p<0.001; however, this corre...Continue Reading

References

Jun 1, 1992·AJR. American Journal of Roentgenology·N L MüllerC V Zwirewich
Jul 1, 1986·Journal of Thoracic Imaging·A G CutilloT A Case
Jan 1, 1984·Investigative Radiology·S SkalinaB Marshall
Feb 1, 1994·The American Journal of Surgical Pathology·A L Katzenstein, R F Fiorelli
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Antonio G CutilloCarl H Durney
May 13, 2005·Chest·Christopher J LettieriAndrew F Shorr
Jul 1, 2005·Radiology·David A LynchTalmadge E King
Jun 2, 2006·Proceedings of the American Thoracic Society·Fernando J Martinez, Kevin Flaherty
Jan 16, 2007·American Journal of Respiratory and Critical Care Medicine·Joo Hun ParkThomas V Colby
Feb 20, 2007·The Annals of Thoracic Surgery·Mary Elizabeth KreiderJoseph B Shrager
Jan 16, 2008·Radiology·David M HansellJacques Remy
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·William D TravisAthol Wells
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grzegorz BaumanLothar R Schad
Nov 26, 2009·Journal of Thoracic Imaging·C Isabela S Silva, Nestor L Müller
May 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Richard E JacobKevin R Minard
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Oct 2, 2012·Archives of Pathology & Laboratory Medicine·Brandon T Larsen, Thomas V Colby
May 16, 2013·American Journal of Respiratory and Critical Care Medicine·Philip A Hodnett, David P Naidich
Aug 15, 2014·Respiration; International Review of Thoracic Diseases·Ute OltmannsMichael Kreuter
Oct 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Scott A HamlinArthur E Stillman
Jun 4, 2015·European Radiology·Maria T A BuzanJulien Dinkel

❮ Previous
Next ❯

Citations

Mar 20, 2019·Thorax·Nicholas D WeatherleyJim M Wild
Feb 6, 2020·International Journal of Molecular Sciences·Chiara GiraudoMassimiliano Casali
Nov 27, 2020·Journal of Magnetic Resonance Imaging : JMRI·Ilyes BenlalaGaël Dournes
Jul 20, 2019·Respiratory Medicine·Lilian LonzettiBruno Hochhegger

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
imaging techniques

Software Mentioned

R
R Foundation for

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.