Texture features on T2-weighted magnetic resonance imaging: new potential biomarkers for prostate cancer aggressiveness

Physics in Medicine and Biology
A VignatiD Regge

Abstract

To explore contrast (C) and homogeneity (H) gray-level co-occurrence matrix texture features on T2-weighted (T2w) Magnetic Resonance (MR) images and apparent diffusion coefficient (ADC) maps for predicting prostate cancer (PCa) aggressiveness, and to compare them with traditional ADC metrics for differentiating low- from intermediate/high-grade PCas. The local Ethics Committee approved this prospective study of 93 patients (median age, 65 years), who underwent 1.5 T multiparametric endorectal MR imaging before prostatectomy. Clinically significant (volume ≥0.5 ml) peripheral tumours were outlined on histological sections, contoured on T2w and ADC images, and their pathological Gleason Score (pGS) was recorded. C, H, and traditional ADC metrics (mean, median, 10th and 25th percentile) were calculated on the largest lesion slice, and correlated with the pGS through the Spearman correlation coefficient. The area under the receiver operating characteristic curve (AUC) assessed how parameters differentiate pGS = 6 from pGS ≥ 7. The dataset included 49 clinically significant PCas with a balanced distribution of pGS. The Spearman ρ and AUC values on ADC were: -0.489, 0.823 (mean); -0.522, 0.821 (median); -0.569, 0.854 (10th percentile...Continue Reading

References

Sep 15, 1998·IEEE Transactions on Medical Imaging·P A Freeborough, N C Fox
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter Gibbs, Lindsay W Turnbull
Dec 20, 2003·Magnetic Resonance Imaging·Doaa Mahmoud-GhoneimJacques D de Certaines
Dec 20, 2003·Magnetic Resonance Imaging·S Herlidou-MêmeJ D de Certaines
Sep 16, 2004·Journal of the National Cancer Institute·Arnold L PotoskyLinda C Harlan
Nov 24, 2004·Clinical Radiology·G CastellanoF Cendes
Dec 15, 2005·IEEE Transactions on Medical Imaging·Anant MadabhushiDeborah Chute
Nov 9, 2006·Virchows Archiv : an International Journal of Pathology·Burkhard Helpap, Lars Egevad
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Weijie ChenGillian M Newstead
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Andrew B RosenkrantzBachir Taouli
May 30, 2012·Physics in Medicine and Biology·Emilie NiafCarole Lartizien
Sep 22, 2012·AJR. American Journal of Roentgenology·Andrew B RosenkrantzSamir S Taneja
Sep 24, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Bo La YunWoo Kyung Moon

❮ Previous
Next ❯

Citations

Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Apr 5, 2016·Urologic Oncology·Ely R FelkerLeonard S Marks
Aug 18, 2016·Future Oncology·Samuel BorofskyMyles Taffel
Oct 30, 2016·Future Oncology·Emanuele Neri, Daniele Regge
Nov 26, 2016·The British Journal of Radiology·Elisa Scalco, Giovanna Rizzo
Sep 20, 2018·Journal of Magnetic Resonance Imaging : JMRI·Tong ChenJunkang Shen
Feb 15, 2019·Australasian Physical & Engineering Sciences in Medicine·Yu SunAnnette Haworth
Nov 6, 2018·Journal of Magnetic Resonance Imaging : JMRI·Rhea D Chitalia, Despina Kontos
Jun 22, 2018·Abdominal Radiology·Clayton P SmithBaris Turkbey
Dec 6, 2019·Der Radiologe·Charlie Alexander HammTobias Penzkofer
Feb 23, 2019·PloS One·Tommy LöfstedtAnders Garpebring
May 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Andreas WibmerHebert A Vargas
Aug 22, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rodrigo DelgadilloRadka Stoyanova
Jun 24, 2020·Physics in Medicine and Biology·Arianna DefeudisValentina Giannini
Dec 6, 2018·Diagnostics·Kyle H GennaroSoroush Rais-Bahrami
May 8, 2019·Journal of Magnetic Resonance Imaging : JMRI·Shuai MaXiaoying Wang
Sep 14, 2016·European Radiology·Harbir S SidhuShonit Punwani
Aug 9, 2019·European Radiology Experimental·Renato CuocoloMassimo Imbriaco
Mar 27, 2020·Journal of Magnetic Resonance Imaging : JMRI·Lixin GongJie Tian
Dec 16, 2017·The British Journal of Radiology·Anne Marie BoustaniLawrence Saperstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.