Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling

PLoS Genetics
Husniye KantarciBruce B Riley

Abstract

Neurons of the statoacoustic ganglion (SAG) transmit auditory and vestibular information from the inner ear to the hindbrain. SAG neuroblasts originate in the floor of the otic vesicle. New neuroblasts soon delaminate and migrate towards the hindbrain while continuing to proliferate, a phase known as transit amplification. SAG cells eventually come to rest between the ear and hindbrain before terminally differentiating. Regulation of these events is only partially understood. Fgf initiates neuroblast specification within the ear. Subsequently, Fgf secreted by mature SAG neurons exceeds a maximum threshold, serving to terminate specification and delay maturation of transit-amplifying cells. Notch signaling also limits SAG development, but how it is coordinated with Fgf is unknown. Here we show that transcription factor Tfap2a coordinates multiple signaling pathways to promote neurogenesis in the zebrafish inner ear. In both zebrafish and chick, Tfap2a is expressed in a ventrolateral domain of the otic vesicle that includes neurogenic precursors. Functional studies were conducted in zebrafish. Loss of Tfap2a elevated Fgf and Notch signaling, thereby inhibiting SAG specification and slowing maturation of transit-amplifying cells. ...Continue Reading

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Citations

Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Husniye KantarciBruce B Riley
Apr 26, 2017·Apoptosis : an International Journal on Programmed Cell Death·Wei LianWensheng Chen
Jun 5, 2019·Development·Brooke E ChambersRebecca A Wingert
Oct 9, 2020·Development·Brooke E ChambersRebecca A Wingert
Apr 9, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bruce B Riley
May 29, 2021·Journal of Anatomy·Kacey MackowetzkyAndrew J Waskiewicz
Apr 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mengjia WengZhenqi Chen

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Methods Mentioned

BETA
transgenic

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