TFC-612, a prostaglandin E1 derivative, enhances fibrinolytic activity in rats

Thrombosis Research
Y MotoyamaT Ono


TFC-612 inhibited thrombus formation on wire coils inserted into the lumen of the inferior vena cava of rats after 5 oral doses of 1.0 and 3.2 mg/kg and subcutaneous doses of 1.0 and 3.2 micrograms/rat/hr. This compound showed slight inhibition of platelet aggregation induced by collagen at 1.0 and 3.2 mg/kg (po) and significant inhibition at 10 mg/kg. TFC-612 had no effect on the plasma coagulation system at 3.2 mg/kg. Conversely, oral doses of 0.32-3.2 mg/kg dose- dependently enhanced fibrinolytic activity as measured by euglobulin clot lysis time and lysis area on fibrin plates by euglobulin fraction. TFC-612 did not enhance fibrinolytic activity in vitro. These results suggest that the enhancement of fibrinolytic activity by TFC-612, which may be due to an increase in tissue plasminogen activator release or reduction of plasminogen activator inhibitors release, contributes to its inhibition of thrombus formation.


Oct 9, 1976·Lancet·L A Carlson, A G Olsson
Sep 1, 1978·Thrombosis Research·D R RosingS E Epstein
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S J Kirtland
Jun 1, 1987·Thrombosis Research·K WintherS Medgyesi
Dec 22, 1973·Lancet·A M GaderJ D Cash
Mar 15, 1983·Thrombosis Research·A SzczeklikM Palester-Chlebowczyk
Jun 1, 1982·Pharmacological Research Communications·A Dembińska-KiećT Zelazny
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·L HolmbergB Astedt
Apr 1, 1980·Thrombosis Research·T KumadaY Abiko
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS
Mar 1, 1965·The American Journal of Physiology·R HOLEMANS

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