TFC-612, a prostaglandin E1 derivative, enhances fibrinolytic activity in rats

Thrombosis Research
Y MotoyamaT Ono

Abstract

TFC-612 inhibited thrombus formation on wire coils inserted into the lumen of the inferior vena cava of rats after 5 oral doses of 1.0 and 3.2 mg/kg and subcutaneous doses of 1.0 and 3.2 micrograms/rat/hr. This compound showed slight inhibition of platelet aggregation induced by collagen at 1.0 and 3.2 mg/kg (po) and significant inhibition at 10 mg/kg. TFC-612 had no effect on the plasma coagulation system at 3.2 mg/kg. Conversely, oral doses of 0.32-3.2 mg/kg dose- dependently enhanced fibrinolytic activity as measured by euglobulin clot lysis time and lysis area on fibrin plates by euglobulin fraction. TFC-612 did not enhance fibrinolytic activity in vitro. These results suggest that the enhancement of fibrinolytic activity by TFC-612, which may be due to an increase in tissue plasminogen activator release or reduction of plasminogen activator inhibitors release, contributes to its inhibition of thrombus formation.

References

Oct 9, 1976·Lancet·L A Carlson, A G Olsson
Sep 1, 1978·Thrombosis Research·D R RosingS E Epstein
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S J Kirtland
Jun 1, 1987·Thrombosis Research·K WintherS Medgyesi
Dec 22, 1973·Lancet·A M GaderJ D Cash
Mar 15, 1983·Thrombosis Research·A SzczeklikM Palester-Chlebowczyk
Jun 1, 1982·Pharmacological Research Communications·A Dembińska-KiećT Zelazny
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·L HolmbergB Astedt
Apr 1, 1980·Thrombosis Research·T KumadaY Abiko
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS
Mar 1, 1965·The American Journal of Physiology·R HOLEMANS

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.