TFE3 is a diagnostic marker for solid pseudopapillary neoplasms of the pancreas

Human Pathology
Yina JiangPeijun Liu

Abstract

Aberrant Wnt signaling is a hallmark of solid pseudopapillary neoplasms (SPNs) of the pancreas. Transcription factor E3 (TFE3) plays a critical role in activation and regulation of the Wnt pathway and is predicted to be a candidate gene implicated in SPN by gene regulatory network analysis. The aim of this study was to evaluate TFE3 as a marker for SPN. Paraffin-embedded tissues of SPN (n = 75) and other primary pancreatic tumors were analyzed, including pancreatic neuroendocrine tumors (n = 17), pancreatic ductal adenocarcinomas (n = 14), pancreatic neuroendocrine carcinomas (n = 4), and acinar cell carcinomas (n = 3). The clinicopathological features were summarized as well. Differentiation of specific pancreatic duct or acinus was not found in any SPN tissue. Morphologic and immunohistochemical results indicated that SPN displays certain characteristics of neuroendocrine cells. Overall, 71 (94.67%) cases of SPN showed nuclear accumulation for TFE3, most of which displayed moderate to intense expression. The TFE3 positive rates in pancreatic neuroendocrine tumor, pancreatic ductal adenocarcinoma, and pancreatic neuroendocrine carcinoma were 23.53%, 14.29%, and 25%, respectively. All 3 cases of acinar cell carcinoma were negat...Continue Reading

References

Jul 6, 2000·Virchows Archiv : an International Journal of Pathology·M KosmahlG Klöppel
May 29, 2002·The EMBO Journal·Ken-ichi YasumotoShigeki Shibahara
Feb 8, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dengfeng CaoRalph H Hruban
Aug 19, 2006·Experimental and Molecular Pathology·Nathash KallichandaSamuel W French
Sep 27, 2006·The American Journal of Surgical Pathology·Caroline GeersSempoux Christine
Sep 29, 2011·Pediatric Blood & Cancer·Olfat IsmaelSeiji Kojima
Jul 6, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennelle C HodgePatricia T Greipp
Mar 25, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aatur D SinghiRaja R Seethala
Jan 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Diego PloperEdward M De Robertis
May 25, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Diego Ploper, Edward M De Robertis
Jun 15, 2016·Annual Review of Cell and Developmental Biology·Nina Raben, Rosa Puertollano
Aug 31, 2016·World Journal of Gastrointestinal Oncology·Vivian WeissChanjuan Shi

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Citations

Jan 21, 2020·Archives of Pathology & Laboratory Medicine·Stefano La Rosa, Massimo Bongiovanni
Jun 19, 2019·Pathology Oncology Research : POR·Attila Zalatnai, Viktória Kis-Orha
May 3, 2019·Diagnostic Pathology·Luting ZhouChaofu Wang
Aug 21, 2020·Journal of Clinical Pathology·Karen Pinto, Runjan Chetty
May 20, 2020·Annals of Surgical Oncology·Feng YangDeliang Fu
Sep 16, 2021·Cancer Communications·Beiping MiaoObul Reddy Bandapalli
Nov 25, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Peyman DinarvandSinchita Roy-Chowdhuri

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