TFG-MET fusion in an infantile spindle cell sarcoma with neural features

Genes, Chromosomes & Cancer
Uta FluckeCristina R Antonescu

Abstract

An increasing number of congenital and infantile sarcomas displaying a primitive, monomorphic spindle cell phenotype have been characterized to harbor recurrent gene fusions, including infantile fibrosarcoma and congenital spindle cell rhabdomyosarcoma. Here, we report an unusual spindle cell sarcoma presenting as a large and infiltrative pelvic soft tissue mass in a 4-month-old girl, which revealed a novel TFG-MET gene fusion by whole transcriptome RNA sequencing. The tumor resembled the morphology of an infantile fibrosarcoma with both fascicular and patternless growth, however, it expressed strong S100 protein immunoreactivity, while lacking SOX10 staining and retaining H3K27me3 expression. Although this immunoprofile suggested partial neural/neuroectodermal differentiation, overall features were unusual and did not fit into any known tumor types (cellular schwannoma, MPNST), raising the possibility of a novel pathologic entity. The TFG-MET gene fusion expands the genetic spectrum implicated in the pathogenesis of congenital spindle cell sarcomas, with yet another example of kinase oncogenic activation through chromosomal translocation. The discovery of this new fusion is significant since the resulting MET activation can po...Continue Reading

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Citations

Sep 7, 2018·Genes, Chromosomes & Cancer·Albert J H SuurmeijerCristina R Antonescu
Jun 21, 2019·The American Journal of Surgical Pathology·Cristina R AntonescuChristopher D Fletcher
Jan 30, 2020·Histopathology·Jessica L DavisAlyaa Al-Ibraheemi
Jan 18, 2020·Head and Neck Pathology·Esther Baranov, Jason L Hornick
Jun 10, 2020·Nature Reviews. Clinical Oncology·Robin GuoAlexander Drilon
Oct 9, 2020·Cold Spring Harbor Molecular Case Studies·Ajay GuptaBhuvana A Setty
Jun 14, 2020·Cancer Discovery·Gonzalo RecondoMark M Awad
Feb 16, 2021·Clinics in Perinatology·Tooba RashidMichael D Deel
Jun 20, 2020·Neoplasia : an International Journal for Oncology Research·Ilaria Di MauroFlorence Pedeutour
Aug 4, 2020·The Journal of Molecular Diagnostics : JMD·Matthew R AvenariusRuthann B Pfau
Apr 15, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alyssa J PenningJessica L Davis
Jun 10, 2021·The American Journal of Surgical Pathology·Megan J FitzpatrickValentina Nardi
May 27, 2021·Genes, Chromosomes & Cancer·Florence ChooJessica L Davis
May 13, 2021·Journal of Cutaneous Pathology·Keisuke GotoArnaud de la Fouchardière
Jun 15, 2021·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Caitlin E HughesJulia Bridge
Aug 12, 2021·Genes, Chromosomes & Cancer·Adela MisoveLenka Krskova
Dec 6, 2021·BMC Genomics·Stephanie LaHayePeter White
Dec 28, 2021·Histopathology·Jessica L DavisLea F Surrey

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