Oct 29, 2018

Stress-induced TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylation

BioRxiv : the Preprint Server for Biology
Roberto FerrariMiguel Beato


The mammalian genome is shaped by the expansion of repetitive elements and its folding is governed by epigenetic modifications and architectural proteins. However, the precise way all these factors interact to coordinate genome structure and expression is poorly understood. Here we report that upon serum starvation TFIIIC, a general transcription factor, binds a subset of Alu elements close to cell cycle genes and rewires genome topology via direct histone acetylation and promoter-anchored chromatin loops to distant genes. These changes ensure basal transcription of crucial cell cycle genes and their re-activation upon serum re-exposure. Our study unveils a novel function of TFIIIC on gene expression and genome folding achieved through casting direct manipulation of the epigenetic state of Alu elements to adjust 3D genome function.

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Mentioned in this Paper

Transcription factor TFIIIC
Gene Editing
TFIIIC-class Transcription Factor Binding
Transcription, Genetic
Gene Deletion Abnormality

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