PMID: 9180219May 16, 1997Paper

T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population

Neuroscience Letters
Y NishiwakiT Ogihara

Abstract

To investigate whether presenilin 1 (PS1) gene, a major causative gene of familial early-onset Alzheimer's disease (AD), also contributes to the etiology of sporadic AD, we evaluated associations between Japanese AD and polymorphisms located at 14q24.3. While the D14S43 and FOS loci showed no association with either early- or late-onset AD, late-onset AD carrying no APOE-epsilon4 allele was associated with the G allele of the T/G polymorphism located at intron 9 of the PS1 gene (P = 0.016). Considering another study showing a positive association between AD and the T allele, this polymorphism is associated with, but not responsible for sporadic late-onset Alzheimer's disease.

References

Apr 11, 1991·Nucleic Acids Research·V SharmaM Litt
Sep 1, 1995·Nature Medicine·W WascoD M Kovacs
Sep 18, 1993·Lancet·S NoguchiN Yamada
Jul 1, 1993·Nature Genetics·Y TakiyamaS Ohta
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Apr 27, 1996·Lancet·W K ScottM A Pericak-Vance
Jun 1, 1996·Lancet·J Pérez-TurM C Chartier-Harlin
Aug 10, 1996·Lancet·M J OwenJ Williams

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Citations

Jul 15, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·H TanimukaiM Takeda
May 18, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M YasudaC Tanaka
Aug 17, 2004·Neuroscience Letters·Paola LucarelliPaolo Curatolo
Aug 28, 2007·Brain Research·Miguel Rodríguez-ManotasJuan Cabezas-Herrera
Nov 20, 2008·Journal of Geriatric Psychiatry and Neurology·Erdinç DursunSelma Yilmazer
Aug 22, 2000·American Journal of Medical Genetics·M B PetersenM Mikkelsen
Nov 28, 2002·Annals of Medicine·Ramón Cacabelos

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