TGF-β and CTGF are Mitogenic Output Mediators of Wnt/β-Catenin Signaling in Desmoid Fibromatosis

Applied Immunohistochemistry & Molecular Morphology : AIMM
Sumi VargheseObiajulu H Iwenofu

Abstract

Desmoid fibromatosis is a locally aggressive clonal fibroblastic proliferation with high recurrence rates and no metastatic potential. Implicated molecular aberrations occur within the Wnt/β-catenin pathway (APC and β-catenin gene mutations). Transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) are profibrotic growth factors, downstream from nuclear translocation of β-catenin, that lead to increased fibrogenesis. CTGF (a downstream effector of TGF-β) is a matricellular protein that modulates the activity of growth factors, adhesion molecules, integrins, and extracellular matrix thus playing a central role in tissue remodeling and fibrosis. Recently there has been growing interest in use of extracellular matrix inhibitors for treatment of various fibrogenic diseases. Desmoid fibromatosis samples (n=15) were evaluated for expression of β-catenin, TGF-β, and CTGF using immunohistochemistry on formalin paraffin-embedded material. A control group comprising scar tissue and adjacent normal skin (n=10) were simultaneously immunostained with above mentioned markers. Real-time polymerase chain reaction was performed on frozen specimens of desmoid fibromatosis (n=6) and normal skin (n=2). All 15 desmoid tumors ...Continue Reading

References

Aug 15, 1994·Cancer·M A Rodriguez-BigasN J Petrelli
Feb 14, 1998·Cytokine & Growth Factor Reviews·G R Grotendorst
Mar 4, 1999·Neuromuscular Disorders : NMD·P BernasconiR Mantegazza
Feb 14, 2004·The Journal of Investigative Dermatology·Andrew LeaskDavid J Abraham
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew Leask, David J Abraham
Apr 16, 2005·The American Journal of Surgical Pathology·Baishali BhattacharyaElizabeth Montgomery
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Makoto GegaTakehira Yamamura
Apr 4, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sophia S CheonBenjamin A Alman
Nov 30, 2006·Journal of Cell Science·Andrew Leask, David J Abraham
Dec 1, 2006·Human Molecular Genetics·Andrew LatchfordAndrew Silver
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dina LevRaphael E Pollock
Jul 3, 2007·Experimental Cell Research·Saeid Amini NikSabine Tejpar
Nov 13, 2007·Journal of the Neurological Sciences·Guilian SunShigeru Tsuchiya
Oct 4, 2008·The American Journal of Pathology·Alexander J F LazarDina Lev
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Mar 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mrinal M GounderRobert G Maki
Apr 12, 2011·The Oncologist·Bernd KasperPeter Hohenberger
Jun 16, 2011·British Journal of Cancer·S BraigA-K Bosserhoff
Aug 10, 2011·The Journal of Pathology·María Gabriela MoralesEnrique Brandan
Jan 30, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Je-Ho MunHyun-Chang Ko
Apr 2, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yuan SunJiahong Xia
Apr 16, 2014·Current Molecular Medicine·P CisternasN C Inestrosa

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