TGF-β and SMADs mRNA Expression in Pulmonary Sarcoidosis

Advances in Experimental Medicine and Biology
W J PiotrowskiE Brzeziańska-Lasota

Abstract

Lung fibrosis is a complication of sarcoidosis, in which TGF-β/Smad pathway may play an important role. We evaluated gene expression of TGF-β1, SMAD2, 3 and 7 in bronchoalveolar lavage (BAL) cells and peripheral blood (PB) lymphocytes of sarcoidosis patients (n=94) to better understand the mechanisms of sarcoid inflammation. The relative gene expression was analyzed by qPCR method. Selected clinical/radiological features and biochemical markers were taken into account in the analysis. We found that TGF-β1 and SMAD3 expressions in PB lymphocytes were significantly higher in sarcoidosis patients. Up-regulation of SMAD7 (inhibitory Smad) and down-regulation of SMAD3 in BAL cells in all subgroups were found. The expression of TGF-β1 in PB lymphocytes was the highest in patients with lung parenchymal involvement and in the insidious onset phenotype. The expression of TGF-β1 in BAL cells was higher in patients with abnormal spirometry (p=0.012), and TGF-β1 and SMAD3 in patients with restrictive pattern (p=0.034 and 0.031, respectively). Several statistically significant negative correlations were found between the expression levels of SMAD2 and 3 in BAL cells and various LFT parameters. We conclude that TGF-β/Smad pathway is involved...Continue Reading

Citations

Oct 21, 2016·Expert Review of Clinical Immunology·Amit ChopraMarc A Judson
Nov 27, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zsuzsa Szondy, Anna Pallai
Sep 9, 2020·Current Opinion in Ophthalmology·De-Kuang Hwang, Shwu-Jiuan Sheu
Jan 6, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna PallaiZsuzsa Szondy
Jul 19, 2016·Current Opinion in Pulmonary Medicine·Alfonso CarleoPaola Rottoli
Jan 10, 2018·Case Reports in Rheumatology·Micah YuKarina D Torralba
Oct 27, 2017·Wiley Interdisciplinary Reviews. RNA·Wendy Ezegbunam, Robert Foronjy
Apr 16, 2020·Journal of Clinical Medicine·Rashi JainJun-O Jin
Jan 16, 2016·BMC Medical Genetics·Justyna KiszałkiewiczEwa Brzeziańska-Lasota
Oct 4, 2020·Current Opinion in Ophthalmology·De-Kuang Hwang, Shwu-Jiuan Sheu

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