TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus.

Cell Communication and Signaling : CCS
Fatemeh YousefiMichael R Hamblin

Abstract

Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found in many pathophysiological heart conditions. A range of molecular components and cellular pathways, have been implicated in its pathogenesis. In this review, we focus on the TGF-β and WNT signaling pathways, and their mutual interaction, which have emerged as important factors involved in cardiac pathophysiology. The molecular and cellular processes involved in the initiation and progression of cardiac fibrosis are summarized. We focus on TGF-β and WNT signaling in cardiac fibrosis, ECM production, and myofibroblast transformation. Non-coding RNAs (ncRNAs) are one of the main players in the regulation of multiple pathways and cellular processes. MicroRNAs, long non-coding RNAs, and circular long non-coding RNAs can all interact with the TGF-β/WNT signaling axis to affect cardiac fibrosis. A better understanding of these processes may lead to new approaches for diagnosis and treatment of many cardiac conditions. Video Abstract.

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Citations

Sep 22, 2020·Expert Review of Molecular Diagnostics·Qianwen WangRuixia Zhu
Jul 31, 2020·Heart Failure Reviews·Mohaddeseh BehjatiMajid Nejati
Jan 12, 2021·Expert Review of Molecular Diagnostics·Chenghao ZhangZhihong Li
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Feb 15, 2021·Gynecologic Oncology·Maryam HashemipourHamed Mirzaei
Feb 12, 2021·Frontiers in Cardiovascular Medicine·Somayeh SaadatHamed Mirzaei
Oct 30, 2020·Frontiers in Physiology·Julia Mester-TonczarMariann Gyöngyösi
Feb 23, 2021·Expert Review of Molecular Diagnostics·Tiantian MaLimeng Chen
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Mar 9, 2021·Frontiers in Genetics·Handong SunHui Jin
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Roberta GiordoGianfranco Pintus
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Jul 11, 2021·Cell Death & Disease·Sangmi OckJaetaek Kim
Jul 25, 2021·Vascular Pharmacology·Xueyuan SunLijuan Huang
Aug 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao LiHan Zhang
Jan 29, 2022·Cellular and Molecular Life Sciences : CMLS·Byeong-Yun AhnJong-Sun Kang

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Methods Mentioned

BETA
nuclear translocation
ubiquitination
two-hybrid
imaging techniques
transgenic
immunoprecipitation
biopsies

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