TGF-β Control of Adaptive Immune Tolerance: A Break From Treg Cells

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Ming LiuMing O Li

Abstract

The vertebrate adaptive immune system has well defined functions in maintaining tolerance to self-tissues. Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor-β (TGF-β) and regulatory T (Treg) cells, a distinct T cell lineage specified by the transcription factor Foxp3. Although TGF-β promotes thymic Treg (tTreg) cell development by repressing T cell clonal deletion and peripheral Treg cell differentiation by inducing Foxp3 expression, a recent study shows that TGF-β suppresses autoreactive T cells independent of Foxp3+ Treg cells. These findings imply that as an ancestral growth factor family member, TGF-β may have been co-opted as a T cell-intrinsic mechanism of self-tolerance control to assist the evolutionary transition of vertebrate adaptive immunity. Later, perhaps in placental mammals upon their acquisition of a TGF-β regulatory element in the Foxp3 locus, the TGF-β pathway is further engaged to induce peripheral Treg cell differentiation and expand the scope of T cell tolerance control to innocuous foreign antigens.

References

Sep 1, 1992·DNA and Cell Biology·D W Burt, I R Paton
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C A Janeway
Jun 29, 2002·Nature Immunology·Irina ApostolouHarald von Boehmer
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Aug 1, 1964·Nature·M BURNET
Oct 26, 2005·Nature Immunology·Karsten KretschmerHarald von Boehmer
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sebastian D FugmannJonathan P Rast
Mar 23, 2006·Annual Review of Immunology·Steven F Ziegler
Nov 7, 2006·Developmental Biology·François LaprazThierry Lepage
Dec 25, 2007·Nature Immunology·Yukiko ToneMasahide Tone
Aug 12, 2008·Cell·Ming O Li, Richard A Flavell
Mar 24, 2009·Annual Review of Immunology·Diane Mathis, Christophe Benoist
Dec 18, 2009·Nature Immunology·Daniel L Mueller
Jan 9, 2010·Science·Philippe Horvath, Rodolphe Barrangou
Jul 24, 2010·Nature Reviews. Immunology·Gary W LitmanSebastian D Fugmann
Jan 10, 2012·Annual Review of Immunology·Steven Z JosefowiczAlexander Y Rudensky
May 17, 2012·Frontiers in Immunology·Kristian G AndersenAlexander G Betz
Aug 22, 2012·The Journal of Experimental Medicine·Susan M SchlennerHarald von Boehmer
Sep 21, 2012·Nature Reviews. Molecular Cell Biology·Joan Massagué
Feb 20, 2015·Nature Communications·Tomohisa OkamuraKazuhiko Yamamoto
Apr 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eörs Szathmáry
Mar 31, 2016·Nature Reviews. Immunology·Ming O Li, Alexander Y Rudensky
Sep 18, 2016·Cold Spring Harbor Perspectives in Biology·Andrew P HinckTimothy A Springer
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kaoru MoritaKeishi Fujio
Apr 4, 2017·Developmental and Comparative Immunology·Kotaro SugimotoKazu Kikuchi
Jul 27, 2017·Biological Reviews of the Cambridge Philosophical Society·Viktor MüllerEörs Szathmáry

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Citations

Nov 12, 2019·CNS Neuroscience & Therapeutics·Yan ZhouXiao-Bing Jiang
Mar 7, 2020·Current Pharmaceutical Design·Gilson P DornelesAlessandra Peres
Feb 1, 2020·Oncoimmunology·Isaure VanmeerbeekAbhishek D Garg
Dec 18, 2018·Frontiers in Immunology·Aleksey Molodtsov, Mary Jo Turk
Jan 4, 2019·Journal of Translational Medicine·Bodo C Melnik, Gerd Schmitz
Jan 11, 2020·Frontiers in Immunology·Usma MunawaraAntonio Ferrante
Oct 9, 2020·Signal Transduction and Targeted Therapy·Siyuan QinWeifeng He
Dec 5, 2020·European Journal of Immunology·Giulio GigantiCristiano Scottà
Dec 28, 2019·Seminars in Cell & Developmental Biology·Monika Lodyga, Boris Hinz
Nov 7, 2020·The Journal of Experimental Biology·Laura M Zimmerman
Jul 27, 2021·Journal de mycologie médicale·Liping LinNi Lin
Jul 3, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Liang WangDapeng Chen
Aug 31, 2021·Journal of Immunology Research·Xuyang GaoJinling Chen

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