TGF-β Family Signaling in Mesenchymal Differentiation

Cold Spring Harbor Perspectives in Biology
Ingo GrafeYuji Mishina

Abstract

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes. We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.

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Citations

Oct 26, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Josephine T TauerFrank Rauch
Dec 25, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Milad Fathi-AchacheloueiAysen Tezcaner
Dec 7, 2019·Toxicology Mechanisms and Methods·Latifa KnaniSergio Minucci
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May 28, 2019·The American Journal of Sports Medicine·Sean M MuirAlicia L Bertone
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May 18, 2018·Biological Trace Element Research·Jingmin ZhangHui Xu
Oct 28, 2020·International Journal of Rheumatic Diseases·Junfeng WangZhenpeng Guan
Oct 18, 2020·International Journal of Molecular Sciences·Jessica JannNathalie Faucheux
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Hongzhou ShenSteve G F Shen
Jan 28, 2021·Stem Cell Research & Therapy·Sophia K TheodossiouNathan R Schiele
Jan 14, 2021·Biology of Reproduction·Ryoki TatebayashiShuichi Matsuyama
Jan 12, 2021·Journal of Bioscience and Bioengineering·Zhongmin WuLiyue Ye
Jan 12, 2021·Journal of Immunology Research·Zhaocheng DongBaoli Liu
Jun 3, 2021·International Journal of Molecular Sciences·Pierre MoffattFrank Rauch

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