TGF-β signaling in cancer

Acta Biochimica Et Biophysica Sinica
Shuchen Gu, Xin-Hua Feng

Abstract

Signals from the transforming growth factor-β (TGF-β) superfamily mediate a broad spectrum of cellular processes and are deregulated in many diseases, including cancer. TGF-β signaling has dual roles in tumorigenesis. In the early phase of tumorigenesis, TGF-β has tumor suppressive functions, primarily through cell cycle arrest and apoptosis. However, in the late stage of cancer, TGF-β acts as a driver of tumor progression and metastasis by increasing tumor cell invasiveness and migration and promoting chemo-resistance. Here, we briefly review the mechanisms and functions of TGF-β signaling during tumor progression and discuss the therapeutic potentials of targeting the TGF-β pathway in cancer.

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Citations

Aug 21, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun FeiJia-Bin Li
Oct 20, 2020·Technology in Cancer Research & Treatment·Binghua DouGuangyao Sheng
Aug 6, 2019·Current Opinion in Cell Biology·Yi Yu, Xin-Hua Feng
Jun 1, 2020·Biochemical and Biophysical Research Communications·Jian-Bo LinMing-Qiang Kang
Nov 7, 2021·Journal of Clinical Laboratory Analysis·Li-Yan JinGuo-Qin Jiang

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