TGF-β signaling in cell fate control and cancer

Current Opinion in Cell Biology
Yi Yu, Xin-Hua Feng

Abstract

Members of the transforming growth factor-β (TGF-β) family regulate cell fate decisions during early embryonic development and tissue homeostasis in the adult. Deregulation of TGF-β family signaling contributes to developmental anomalies, fibrotic disorders, tumorigenesis and immune diseases. TGF-β exerts a wide spectrum of cellular functions by activating canonical (SMAD-dependent) or non-canonical (SMAD-independent) pathways in a cell type-specific and context-dependent manner. Here, we focus on recent advances in the understanding of the mechanisms and functions of SMAD and non-SMAD pathways in physiology and pathology.

References

Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joseph M ScanduraStephen D Nimer
Jun 20, 2006·Immunity·Casey T WeaverKenneth M Murphy
Jul 4, 2007·Proceedings of the American Thoracic Society·Yisong Y Wan, Richard A Flavell
Jul 30, 2008·Cell·Joan Massagué
Aug 12, 2008·Cell·Ming O Li, Richard A Flavell
Jun 12, 2010·European Journal of Immunology·David S J AllanJack L Strominger
Dec 27, 2011·Cell·Qiaoran XiJoan Massagué
Sep 21, 2012·Nature Reviews. Molecular Cell Biology·Joan Massagué
Aug 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shinji TakaiJohn W Greiner
Feb 8, 2014·Seminars in Cell & Developmental Biology·Tessa Gaarenstroom, Caroline S Hill
Mar 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sarah S DonatelliJulie Y Djeu
May 6, 2015·Cell·Holger Heyn, Manel Esteller
May 4, 2016·Cold Spring Harbor Perspectives in Biology·Masato MorikawaKohei Miyazono
Oct 13, 2016·Scientific Reports·Mayu MoritaTakeshi Miyamoto
Nov 20, 2016·Cold Spring Harbor Perspectives in Biology·Ying E Zhang
Dec 7, 2016·Molecular and Cellular Biology·Courtney M KarnerFanxin Long
Mar 7, 2017·Nature Communications·Patrick Ming-Kuen TangHui-Yao Lan
Sep 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yi YuXin-Hua Feng
Feb 15, 2018·Nature·Daniele V F TaurielloEduard Batlle
Apr 13, 2018·Nature Reviews. Molecular Cell Biology·Charles J David, Joan Massagué

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Citations

Oct 23, 2019·Frontiers in Oncology·Weina YuYi Zhang
Apr 2, 2020·Expert Opinion on Therapeutic Targets·Christopher LarsonTony R Reid
Sep 10, 2020·Science Signaling·Lucy MacCarthy-Morrogh, Paul Martin
May 15, 2020·Nature Communications·Likhitha KollaMatthew W Kelley
Jun 2, 2020·Frontiers in Cardiovascular Medicine·Pei-Yu ChenMichael Simons
Oct 22, 2020·Critical Reviews in Biochemistry and Molecular Biology·Charlotte de Ceuninck van CapellePeter Ten Dijke
Nov 19, 2020·Molecular Oncology·Antonia Schubert, Michael Boutros
Dec 15, 2020·Journal of Experimental & Clinical Cancer Research : CR·Qiuling NiuXinke Zhou
Dec 20, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Kegui ZhangXiaohua Yan
Sep 30, 2020·Trends in Genetics : TIG·Hatem Elif Kamber Kaya, Senthil K Radhakrishnan
Dec 28, 2019·Seminars in Cell & Developmental Biology·Monika Lodyga, Boris Hinz
Feb 23, 2021·Frontiers in Immunology·Min ChaoLiang Wang
Mar 8, 2021·The Journal of Biological Chemistry·Junbo LiangWei Song
Mar 14, 2021·Development·Shunji Jia, Anming Meng
Jul 20, 2020·Biochemical Pharmacology·Xinran Li, Xin-Hua Feng
Jun 3, 2021·Genes·Chi-Ting Su, Zsolt Urban
Jul 20, 2021·Frontiers in Cell and Developmental Biology·Ran ZhangGuan Yang
Aug 11, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yujuan JinHongbin Ji
Aug 15, 2021·Applied Microbiology and Biotechnology·Shouli YuanWanzhu Jin
Aug 31, 2021·Molecular Therapy. Nucleic Acids·Yebo ShaoJunyi He
Aug 8, 2021·Cancer Research·Jinquan LiuXin-Hua Feng
Oct 13, 2021·Cell Death Discovery·Shanshan ZhaoSong Zhang
Dec 4, 2021·The Journal of Cell Biology·Jun ZhouXinlai Cheng

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