TGF-β1 and TGF-β2 abundance in liver diseases of mice and men

Oncotarget
Anne DropmannNadja M Meindl-Beinker

Abstract

TGF-β1 is a major player in chronic liver diseases promoting fibrogenesis and tumorigenesis through various mechanisms. The expression and function of TGF-β2 have not been investigated thoroughly in liver disease to date. In this paper, we provide evidence that TGF-β2 expression correlates with fibrogenesis and liver cancer development.Using quantitative realtime PCR and ELISA, we show that TGF-β2 mRNA expression and secretion increased in murine HSCs and hepatocytes over time in culture and were found in the human-derived HSC cell line LX-2. TGF-β2 stimulation of the LX-2 cells led to upregulation of the TGF-β receptors 1, 2, and 3, whereas TGF-β1 treatment did not alter or decrease their expression. In liver regeneration and fibrosis upon CCl4 challenge, the transient increase of TGF-β2 expression was accompanied by TGF-β1 and collagen expression. In bile duct ligation-induced fibrosis, TGF-β2 upregulation correlated with fibrotic markers and was more prominent than TGF-β1 expression. Accordingly, MDR2-KO mice showed significant TGF-β2 upregulation within 3 to 15 months but minor TGF-β1 expression changes. In 5 of 8 hepatocellular carcinoma (HCC)/hepatoblastoma cell lines, relatively high TGF-β2 expression and secretion were ...Continue Reading

References

Jun 26, 1992·Cell·J Massagué
Mar 1, 1988·Japanese Journal of Cancer Research : Gann·K AbeT Shikata
Feb 1, 1989·Molecular Endocrinology·P R SegariniS M Seyedin
Sep 1, 1996·Ultrastructural Pathology·A O WilliamsA B Roberts
Apr 1, 1997·Journal of Hepatology·P J De BleserA Geerts
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S Roth-EichhornA M Gressner
Feb 2, 1999·Journal of Hepatology·C HellerbrandD A Brenner
Apr 29, 1999·American Journal of Surgery·M Abou-ShadyM W Büchler
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
Oct 5, 2001·Nature Genetics·R DerynckA Balmain
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 12, 2002·Molecular Biology of the Cell·Xin ChenPatrick O Brown
Apr 13, 2004·European Journal of Gastroenterology & Hepatology·Fanny W Shek, R Christopher Benyon
Apr 30, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Pinzani, K Rombouts
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Nov 18, 2005·Cytokine & Growth Factor Reviews·Brian Bierie, Harold L Moses
Nov 29, 2005·Cytokine & Growth Factor Reviews·Laurence Levy, Caroline S Hill
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eliza WiercinskaSteven Dooley
Jun 24, 2006·Nature Reviews. Cancer·Brian Bierie, Harold L Moses
Apr 1, 1996·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·G Serini, G Gabbiana
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hu-Liang JiaXin Wei Wang
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa WurmbachJosep M Llovet
Jun 15, 2007·Journal of Cellular Physiology·George K Michalopoulos
Nov 21, 2007·Molecular Cancer Research : MCR·Mark KatzenellenbogenDaniel Goldenberg
May 13, 2008·Gastroenterology·Scott L Friedman
May 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cédric CoulouarnSnorri S Thorgeirsson
Aug 15, 2008·Cancer Research·Derek Y ChiangJosep M Llovet
Oct 29, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kellie J ArcherRobert A Fisher
Jun 23, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Michael SigalChristian Eipel

❮ Previous
Next ❯

Citations

Aug 6, 2016·Scandinavian Journal of Immunology·Y-Y SunJ Li
Aug 22, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mai Abd El-MeguidMostafa K El Awady
May 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew McMillinSharon DeMorrow
Nov 14, 2019·Cells·Bedair DewidarAnd Nadja Meindl-Beinker
Jan 30, 2020·Gut·Anne DropmannNadja M Meindl-Beinker
Sep 1, 2020·Expert Review of Molecular Diagnostics·Steffen K MeurerRalf Weiskirchen
Dec 14, 2018·Experimental & Molecular Medicine·Zhezhu HanJae J Song
Jul 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reina SasakiRanjit Ray
Apr 9, 2020·Cells·Natascha RoehlenThomas F Baumert
Aug 8, 2020·Italian Journal of Pediatrics·Gang ShenHuixian Liu
Aug 28, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Reham M DawoodMostafa K El Awady
Jun 7, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Stefania Di MauroSalvatore Piro
Jan 26, 2021·Redox Biology·M Herranz-ItúrbideI Fabregat
Aug 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zuliang HuYanwen Liu
Aug 6, 2021·Science Translational Medicine·Tianhe SunJoseph R Arron
Oct 5, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ningning LiuGuisheng Song

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE14520

Methods Mentioned

BETA
ELISA
PCR
antisense oligonucleotide
density gradient centrifugation
transgenic
chip
antisense oligonucleotides
transfection
ELISAs

Software Mentioned

Bioconductor (
GraphPad Prism
Fluidigm

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.