TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population

Revista Da Sociedade Brasileira De Medicina Tropical
Fabiane Vieira Berg ShehadehSandra Mara Alessi Aristides

Abstract

Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.

References

Nov 1, 1995·The Journal of Experimental Medicine·M CabreraJ M Blackwell
Apr 2, 2003·The Journal of Antimicrobial Chemotherapy·Pierre Delobel, Roger Pradinaud
Nov 28, 2007·Journal of Medical Virology·Fernanda Albuquerque PereiraMitermayer Galvão Reis
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adnene SalhiAlain Dessein
Mar 11, 2010·Tropical Medicine & International Health : TM & IH·T N SamaranayakeV H W Dissanayake
Mar 8, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Amanda Farage FradeAnna Carla Goldberg

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Citations

Mar 23, 2021·Expert Review of Clinical Immunology·Daniele Stéfanie Sara Lopes Lera-NonoseMaria Valdrinez Campana Lonardoni

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