PMID: 8583244Oct 1, 1995Paper

TGF alpha expression in meningioma--tumor progression and therapeutic response

Journal of Neuro-oncology
R M LinggoodF S Pardo

Abstract

Little is known of the molecular genetic mechanisms contributing to meningioma tumor progression. We evaluated a total of 26 clinical cases of meningioma: twenty three patients with meningioma treated at our institution between 1978 and 1990 and three asymptomatic cases found initially at autopsy. In addition, histologically normal meninges obtained at post-mortem examination from 5 cases were evaluated. There were 13 men and 10 women in the patient group with a median age of 48.7 years, treated by surgery and/or irradiation. Median follow-up was 46 months (range 16-152 months). Archival cases and age-matched normal meningeal tissue obtained at autopsy during the same time period were obtained for study. Patients with TGF alpha scores greater than 3.0 were more likely to fail treatment and had lower overall survival times than those with immunostaining scores of 1 or 2. Three autopsy cases where meningioma had been silent clinically had overall staining scores of 0.75, while 10 samples of normal meninges harvested from 5 cases at autopsy had staining scores of 0. Two patients each underwent 3 surgeries for recurrent tumor, serial specimens showed increased TGF alpha expression over time, though all material from these procedure...Continue Reading

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Citations

Jun 30, 2009·Journal of Neuro-oncology·Andrew D NordenPatrick Y Wen
Jun 1, 1997·International Journal of Radiation Oncology, Biology, Physics·K T ColvettF S Pardo
May 25, 2012·PloS One·Angélique GuillaudeauFrançois Labrousse
Oct 27, 2007·Neurosurgical Focus·Andrew D NordenPatrick Y Wen
Aug 1, 1997·Journal of Neurosurgery·R S CarrollA Guha
Nov 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·David S BaxterTiit Mathiesen
Nov 3, 2006·Expert Review of Neurotherapeutics·Patrick Y Wen, Jan Drappatz
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Mahlon Johnson, Steven Toms
Apr 3, 2018·Neurosurgical Focus·Saksham GuptaIan F Dunn
May 1, 2010·Experimental and Therapeutic Medicine·Choong Hyun KimJae Min Kim
Jul 13, 2007·Journal of Neuro-oncology·Mahlon D JohnsonSteven A Toms
Sep 8, 2010·Journal of Neuro-oncology·Patrick Y WenAndrew D Norden
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael HaganPaul Dent

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