PMID: 2110031Apr 20, 1990Paper

TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence

Cell
L D KerrL M Matrisian

Abstract

Transforming growth factor beta 1 (TGF-beta 1) inhibits the growth factor and oncogene induction of transin/stromelysin, a secreted matrix-degrading metalloprotease. We demonstrate that a 10 bp element in the transin promoter is required for the TGF-beta 1 inhibitory effects and that this sequence is conserved in the promoter regions of several other TGF-beta 1-inhibited genes. The TGF-beta 1 inhibitory element (TIE) specifically binds a nuclear protein complex from TGF-beta 1-stimulated rat fibroblasts. Interestingly, this complex contained the c-fos proto-oncogene product, Fos, and induction of Fos expression was required for the inhibitory effect of TGF-beta 1 on transin gene expression. These results suggest that TGF-beta 1 inhibition of gene expression is mediated by the binding of a Fos-containing protein complex to the TIE promoter sequences.

References

Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J Skowronski, M F Singer
Dec 22, 1989·Science·J L SonnenbergT Curran
Jul 28, 1988·Nature·P Sassone-CorsiI M Verma
Jul 1, 1988·The Biochemical Journal·D MullerR Breathnach
Dec 15, 1988·Nature·T Kouzarides, E Ziff
Apr 25, 1985·Nucleic Acids Research·A RiccioF Blasi
Dec 15, 1986·The Biochemical Journal·S E WhithamA J Docherty
May 16, 1988·Biochemical and Biophysical Research Communications·U S MurthyR Greig
Nov 4, 1988·Cell·T Curran, B R Franza
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WilhelmG I Goldberg
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J T HoltA W Nienhuis
Dec 1, 1986·Molecular and Cellular Biology·M W KingR N Eisenman
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L M MatrisianR Breathnach
Jan 1, 1985·Molecular and Cellular Biology·T CurranI M Verma
Aug 1, 1973·Virology·F L Graham, A J van der Eb
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Jan 11, 1984·Nucleic Acids Research·D Shalloway, N R Deering

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Citations

Mar 1, 1996·Journal of Cellular Biochemistry·C JonatV M Baragi
Feb 15, 2001·Microscopy Research and Technique·K KoliJ Keski-Oja
Sep 1, 1996·The Prostate·W C PowellG T Bowden
Aug 1, 1994·Arthritis and Rheumatism·M P VincentiC E Brinckerhoff
Jul 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Alevizopoulos, N Mermod
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R M ZwackaJ F Engelhardt
Dec 1, 1993·Journal of Cellular Biochemistry·A Mauviel
Oct 1, 1994·The Journal of Experimental Zoology·M D'AngeloR M Greene
Jun 1, 1992·Molecular Reproduction and Development·L M MatrisianL D Wood
Jun 1, 1992·Molecular Reproduction and Development·H L Moses
Jul 1, 1993·Molecular Reproduction and Development·P WaterhouseR Khokha
Dec 1, 1990·Cancer Metastasis Reviews·S McDonnell, L M Matrisian
Mar 1, 1994·Cancer Metastasis Reviews·K Cole, E Kohn
May 15, 1993·Experientia·R V Iozzo, I Cohen
Jun 6, 1993·Biochimica Et Biophysica Acta·H ZhouP C Billings
Sep 1, 1991·Molecular and Cellular Endocrinology·M BerwaerJ A Martial
Sep 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·I ViardJ M Saez
Feb 1, 1996·The International Journal of Biochemistry & Cell Biology·C L Wilson, L M Matrisian

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