TGF-beta in cancer and as a therapeutic target

Biochemical Pharmacology
Jan Pinkas, Beverly A Teicher

Abstract

Cancer develops through a series of genetic changes leading to malignant transformation. Numerous gene and pathways involved in stages of progression to frank malignancy have been elucidated. These genetic changes result in aberrations in fundamental cellular processes controlling proliferation, apoptosis, differentiation and genomic stability. Metastasis is the hallmark of malignancy. The process of metastasis is extremely complex and involves steps including dissemination of tumor cells from the primary tumor through the vascular and lymphatic system and growth selectively in distant tissues and organs. Transforming growth factor-beta which is a growth suppressive cytokine in many normal situations becomes an active and important participant in malignant disease including angiogenesis, extracellular matrix deposition, immuno-suppression and metastasis growth promotion. Transforming growth factor-beta and its receptors are targets for antibody therapeutics and small molecule kinase inhibitors.

References

Jan 1, 1990·Cancer Investigation·D J Slamon
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·B A TeicherG Chen
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Mar 20, 2003·Current Drug Targets·Diana Bello-DeOcampo, Donald J Tindall
Oct 15, 2003·Nature Reviews. Cancer·Peter M Siegel, Joan Massagué
Feb 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Boris PascheTongzhang Zheng
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Sep 8, 2004·International Journal of Cancer. Journal International Du Cancer·Ignacio F San FranciscoAria F Olumi
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eiji SuzukiSteven M Albelda
Dec 2, 2004·Nature Reviews. Drug Discovery·Jonathan M YinglingJ Scott Sawyer
Nov 18, 2005·Cytokine & Growth Factor Reviews·Brian Bierie, Harold L Moses
Nov 29, 2005·Cytokine & Growth Factor Reviews·Laurence Levy, Caroline S Hill

❮ Previous
Next ❯

Citations

Nov 28, 2012·Archives of Gynecology and Obstetrics·Hugo López-MuñozLuis Sánchez-Sánchez
Oct 9, 2008·Breast Cancer Research and Treatment·Antoinette R TanMichael Reiss
Nov 13, 2009·Bulletin of Mathematical Biology·Yangjin Kim, Avner Friedman
Dec 13, 2006·Future Oncology·Amy J GalliherWilliam P Schiemann
Dec 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Feng MiaoHui-Mian Xu
Jan 29, 2014·Future Medicinal Chemistry·Sankar N Krishna, Raymond C Bergan
Oct 30, 2010·Medical Hypotheses·Kamran MansouriMaryam Keshavarz
Apr 18, 2009·British Journal of Pharmacology·Z ZídekE Kmonícková
Mar 20, 2008·Expert Opinion on Therapeutic Targets·Michelle Simpson-Abelson, Richard B Bankert
Dec 18, 2007·The Journal of Urology·Timothy C BrandSusan L Naylor
May 3, 2008·Trends in Pharmacological Sciences·Michal Schwartz, Yaniv Ziv
Mar 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Manav Korpal, Yibin Kang
Dec 14, 2016·IEEE Transactions on Bio-medical Engineering·Yangjin KimHans Othmer
Aug 29, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gérald J Prud'homme
Jul 20, 2006·Journal of the National Cancer Institute·Francesca TosettiAdriana Albini
Feb 25, 2009·Expert Opinion on Therapeutic Targets·Elisabeth JonesNatasha Kyprianou
Mar 29, 2013·Molecular Cancer Therapeutics·Xiaohai WangChawnshang Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.