PMID: 9525697Apr 3, 1998Paper

TGF-beta in renal development and renal growth

Mineral and Electrolyte Metabolism
D P Basile, M R Hammerman

Abstract

Organogenesis of the metanephric kidney is regulated by a number of polypeptide growth factors. Members of the TGF-beta family of growth factors have been shown to be produced in kidney during its development. Available evidence suggests that some of these members play key roles in metanephrogenesis by regulating the process of ureteric bud arborization. The regeneration of the S3 segment of the proximal tubule that occurs following ischemic injury recapitulates in many ways the renal developmental paradigm. The expression of TGF-beta in regenerating kidney is tightly regulated postischemia. We suggest that TGF-beta plays a key role in the repair process following injury and mediates some of the cellular events common to both regeneration and nephrogenesis.

Citations

Aug 10, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hyung Eun YimJoo Won Lee
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y H ChiangY Wang
Sep 6, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M Cecilia CirioNeil A Hukriede
Jul 28, 2012·Seminars in Nephrology·Herbert Y Lin
May 15, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jean-Paul Duong Van HuyenMartine Lelièvre-Pégorier
Jun 22, 2000·Genesis : the Journal of Genetics and Development·S Y PlisovA O Perantoni
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M J SolhaugK W Dong
Nov 10, 2020·American Journal of Physiology. Renal Physiology·Yan ZhangDarren P Wallace
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·Chul Woo YangByung Kee Bang

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