TGF-beta latency: biological significance and mechanisms of activation

Stem Cells
P E GleizesD B Rifkin

Abstract

Transforming growth factor (TGF-) beta is secreted as a latent complex in which the mature growth factor remains associated with its propeptide. In order to elicit a biological response, the cytokine must be released from the latent complex, a process termed latent TGF-beta activation or TGF-beta formation. Although latent TGF-beta activation is a critical step in the regulation of its activity, little is known about the molecular mechanisms that lead to the production of active TGF-beta. In this article, we present an overview of the data available on this topic, and we propose a tentative model for the mechanism of TGF-beta formation based upon the observations with different cell systems and on recent findings on the structure of the latent TGF-beta complex.

References

Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P A Dennis, D B Rifkin
Jan 1, 1991·Methods in Enzymology·D A Lawrence
Apr 1, 1990·The Journal of Cell Biology·R M LyonsH L Moses
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T TsujiT Nakamura
Mar 9, 1989·Nature·K Miyazono, C H Heldin
Jan 1, 1989·Connective Tissue Research·L F Bonewald, G R Mundy
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Antonelli-OrlidgeP A D'Amore
Feb 15, 1989·Biochemical and Biophysical Research Communications·R O OreffoL F Bonewald
Dec 1, 1995·Nature Genetics·G ProetzelT Doetschman
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K SellheyerD R Roop
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·N SandersonS S Thorgeirsson
Apr 28, 1995·The Journal of Biological Chemistry·W YinJ Bonadio
May 5, 1995·The Journal of Biological Chemistry·C M DuboisR Leduc
May 1, 1995·Journal of Neuropathology and Experimental Neurology·E GalbreathA Messing
May 29, 1995·International Journal of Cancer. Journal International Du Cancer·J BoulangerM Koutsilieris
Feb 1, 1994·The Journal of Clinical Investigation·M H Barcellos-HoffJ A Weatherbee
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·R J DieboldT Doetschman

❮ Previous
Next ❯

Citations

Oct 13, 2001·Molecular Reproduction and Development·J YangR J Wall
Jul 23, 2013·The International Journal of Biochemistry & Cell Biology·Justyna Mikuła-PietrasikKrzysztof Książek
Apr 20, 2005·Neurobiology of Disease·Rodrigo Herrera-Molina, Rommy von Bernhardi
Oct 31, 2001·Journal of Immunological Methods·M L Garba, J A Frelinger
Dec 2, 1998·Journal of Hepatology·E Olaso, S L Friedman
Oct 3, 2002·Cellular Signalling·Marion Lutz, Petra Knaus
Mar 22, 2002·Progress in Retinal and Eye Research·M Francesca Cordeiro
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dat Q TranEthan M Shevach
Jul 27, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Iris IsufiAmit Verma
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Ping-Fang HuWei-Fen Xie
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Steven E MutsaersSteven Idell
Aug 5, 2011·Clinical and Vaccine Immunology : CVI·Zhi-Jian YeHuan-Zhong Shi
May 7, 2010·Journal of Biomedicine & Biotechnology·Andrzej SzkaradkiewiczEwa Andrzejewska
Jul 29, 2009·Circulation·Peter MattUNKNOWN GenTAC Consortium
Oct 6, 2007·American Journal of Respiratory and Critical Care Medicine·Gerald S HoranShelia M Violette
Aug 16, 2003·American Journal of Respiratory Cell and Molecular Biology·John W SteinkeLarry Borish
Jan 10, 2002·The Journal of Clinical Investigation·Mai-Lan N HuynhPeter M Henson
Dec 20, 2000·The Journal of Clinical Investigation·D J Loskutoff, J P Quigley
Sep 26, 2007·Respiratory Research·Ynuk Bossé, Marek Rola-Pleszczynski
Apr 12, 2006·Journal of Inflammation·Frank J LichtenbergerClay B Marsh
Sep 27, 2008·Journal of Leukocyte Biology·Andrew W Taylor
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M DangeloM Pacifici
Dec 10, 2013·Annual Review of Immunology·Mark A Travis, Dean Sheppard
Feb 17, 2001·Biochemical and Biophysical Research Communications·Y YasudaN Hotta
Mar 14, 2002·Current Rheumatology Reports·Yan Zhang, Anita C Gilliam
Jul 27, 2001·Journal of Cellular Physiology·L YangM G Brattain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.