TGF-beta regulation by Emilin1: new links in the etiology of hypertension

Cell
Malavika Raman, Melanie H Cobb

Abstract

Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-beta signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-beta signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-beta signaling in the vasculature.

References

Mar 10, 2001·Cell·R P LiftonD S Geller
Dec 17, 2002·Journal of Cell Science·Justin P AnnesDaniel B Rifkin
Mar 15, 2006·Cell·Luca ZacchignaGiorgio M Bressan

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Citations

Mar 14, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nabil G Seidah, Annik Prat
Jun 13, 2006·Minnesota Medicine·Scott D Smith
Jun 25, 2009·Pharmacological Reviews·Hannu JärveläinenRisto Penttinen
Mar 21, 2018·Journal of Cardiovascular Translational Research·Xiaoyan LiuJun Cai
Jun 4, 2020·International Journal of Molecular Sciences·Christian G M van DijkCaroline Cheng

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