TGF-beta1-conditioned glial cell-derived dendritic cells inhibit expansion of MBP-reactive T cells in vitro

Neuroreport
Ling-yun XuBao-guo Xiao

Abstract

Resident microglial cells contribute to activation and expansion of T cells under inflammatory conditions within the CNS. However, there is no evidence how interactions between microglia and T cells affect CNS inflammation. We evaluated the effect of glial cell-derived dendritic cells (GC-DC) in expanding and eliminating myelin basic protein (MBP)-reactive T cells. GC-DC untreated with TGF-beta1 (GC-DC0) primed antigen specific T cell proliferation, whereas GC-DC treated with TGF-1 (GC-DCbeta) effectively inhibited expansion of T cells via inducing IFN-y-expressing CD8+ T cells. Augmented IFN-gamma and/orTNF-alpha might also affect the elimination of MBP-reactive T cells. These results indicate that TGF-beta1-mediated functional skewing of GC-DC plays a critical role for the elimination of MBP-reactive T cells.

References

Jul 28, 1999·International Immunology·H G Fischer, A K Bielinsky
Jan 15, 2000·Advances in Experimental Medicine and Biology·F Aloisi
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Prévost-BlondelH Pircher
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H G FischerG Reichmann
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May 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SantambrogioR Riese

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Citations

Aug 6, 2003·FEMS Immunology and Medical Microbiology·Kenneth W Beagley, Christine M Gockel
Jun 1, 2012·Cellular and Molecular Bioengineering·Christina M WarboysPeter D Weinberg

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