PMID: 15240683Jul 9, 2004Paper

TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways

The Journal of Immunology : Official Journal of the American Association of Immunologists
Y LeJi Ming Wang

Abstract

Human formyl peptide receptor-like 1 and its mouse homologue formyl peptide receptor 2 (FPR2) are G protein-coupled receptors used by a number of exogenous and host-derived chemotactic peptides, including the 42 aa form of beta amyloid peptide, a causative factor of Alzheimer's disease. Functional FPR2 was induced by bacterial LPS in murine microglial cells, the resident phagocytic cells that play a pivotal role in inflammatory and immunological diseases in the CNS. To identify agents that may suppress microglial cell activation under proinflammatory conditions, we investigated the effect of TGF-beta1 on the expression of functional FPR2 by microglial cells activated by LPS. TGF-beta1 dose-dependently inhibited the mRNA expression and function of FPR2 in LPS-activated microglial cells. The inhibitory effect of TGF-beta1 was mediated by Smad3, a key signaling molecule coupled to the TGF-beta receptor, and the transcription coactivator, p300. Also, TGF-beta1 activates MAPKs in microglial cells that became refractory to further stimulation by LPS. These effects of TGF-beta1 culminate in the inhibition of LPS-induced activation of NF-kappaB and the up-regulation of FPR2 in microglial cells. Thus, TGF-beta1 may exert a protective ro...Continue Reading

References

Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A PerrellaM E Lee
Feb 3, 1997·The Journal of Experimental Medicine·D FerrariF Di Virgilio
May 23, 1998·Annual Review of Immunology·J J Letterio, A B Roberts
Jul 1, 1998·International Reviews of Immunology·N L McCartney-FrancisS M Wahl
Jul 25, 1998·Genes & Development·R JanknechtT Hunter
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J N TopperM A Gimbrone
Jan 23, 1999·Current Opinion in Hematology·R N Kalaria
Mar 10, 2000·Cytokine & Growth Factor Reviews·K M Mulder
Feb 7, 2001·Biochemical and Biophysical Research Communications·T S LiangJ L Gao
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Mar 21, 2001·Cellular Signalling·M Guha, N Mackman
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H YazawaJ M Wang
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·You-Hong CuiJi Ming Wang
Mar 23, 2002·Biochimica Et Biophysica Acta·Tsuneyasu Kaisho, Shizuo Akira
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael W VaughnDavid L Haviland
Jan 30, 2003·Annals of Medicine·Peter T NelsonEhud Lavi
Mar 5, 2003·Journal of the Neurological Sciences·Kevin D Barron
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo IribarrenJi Ming Wang

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Citations

Feb 3, 2007·The EMBO Journal·Hajime IshinagaJian-Dong Li
Oct 26, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigenobu MatsumuraTohru Fushiki
Oct 7, 2015·Molecular BioSystems·Warren D AndersonRajanikanth Vadigepalli
Apr 22, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Xiao ChenYu-Ping Peng
Dec 7, 2010·American Journal of Respiratory Cell and Molecular Biology·Ivana V YangDavid A Schwartz
Nov 19, 2015·Frontiers in Cellular Neuroscience·Rommy von BernhardiJaime Eugenín
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria A BauseroAlexzander Asea
Apr 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongjie PanSandhya A Lagoo-Deenadayalan
Apr 17, 2015·Neural Regeneration Research·Fang-Fang LiuLei Song
Sep 6, 2012·Journal of Neuroinflammation·Xiaolai ZhouKerstin Krieglstein
Sep 12, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Felicity N E GavinsJulia C Buckingham
Feb 11, 2020·Frontiers in Endocrinology·Weiwei LiangJi Ming Wang
Mar 10, 2007·Journal of Neuroscience Research·Myung-Soon YangEunhye Joe
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mary E Hamby, Michael V Sofroniew
Apr 7, 2016·Cellular and Molecular Neurobiology·Yongwei QinChun Cheng
Nov 21, 2013·Journal of Neurochemistry·Kendall MitchellAviva J Symes
Oct 4, 2020·Journal of Clinical Medicine·Stefania VernazzaSergio Claudio Saccà
Aug 4, 2020·Trends in Immunology·Björn SpittauMarco Prinz
Nov 9, 2005·International Immunopharmacology·Yingying LeJi Ming Wang

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