TGF-beta1-induced long-term changes in neuronal excitability in aplysia sensory neurons depend on MAPK

Journal of Neurophysiology
Jeannie ChinJohn H Byrne

Abstract

Transforming growth factor beta-1 (TGF-beta1) plays important roles in the early development of the nervous system and has been implicated in neuronal plasticity in adult organisms. It induces long-term increases in sensory neuron excitability in Aplysia as well as a long-term enhancement of synaptic efficacy at sensorimotor synapses. In addition, TGF-beta1 acutely regulates synapsin phosphorylation and reduces synaptic depression induced by low-frequency stimuli. Because of the critical role of MAPK in other forms of long-term plasticity in Aplysia, we examined the role of MAPK in TGF-beta1-induced long-term changes in neuronal excitability. Prolonged (6 h) exposure to TGF-beta1 induced long-term increases in excitability. We confirmed this finding and now report that exposure to TGF-beta1 was sufficient to activate MAPK and increase nuclear levels of active MAPK. Moreover, TGF-beta1 enhanced phosphorylation of the Aplysia transcriptional activator cAMP response element binding protein (CREB)1, a homologue to vertebrate CREB. Both the TGF-beta1-induced long-term changes in neuronal excitability and the phosphorylation of CREB1 were blocked in the presence of an inhibitor of the MAPK cascade, confirming a role for MAPK in long-...Continue Reading

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Citations

Dec 27, 2011·Nature Neuroscience·Yili ZhangJohn H Byrne
Feb 7, 2008·Nature Reviews. Neuroscience·Serena ZacchignaPeter Carmeliet
Jul 11, 2013·PloS One·Phillip A VanlandinghamBing Zhang
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alcmène ChalazonitisEric J Huang
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diasinou FioravanteJohn H Byrne
Jul 12, 2011·Trends in Neurosciences·Kerstin KrieglsteinChristian Alzheimer
Jun 11, 2015·Scientific Reports·Filippo CaraciAgostino Palmeri
Aug 16, 2014·Neurochemistry International·Luan Pereira DinizFlávia Carvalho Alcantara Gomes
Aug 10, 2016·Journal of Cell Science·Eleni RoussaKerstin Krieglstein
Nov 1, 2018·Molecular Neurobiology·Luan Pereira DinizFlávia Carvalho Alcantara Gomes
Mar 12, 2008·Acta Biochimica Et Biophysica Sinica·Yujuan ZhouRongqing Zhang
Nov 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Iksung JinRobert D Hawkins
Apr 11, 2017·Frontiers in Cellular Neuroscience·Qing ChengGeorge J Augustine

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