TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II

The Journal of Clinical Investigation
Jo El J SchultzT Doetschman

Abstract

Angiotensin II (Ang II), a potent hypertrophic stimulus, causes significant increases in TGFb1 gene expression. However, it is not known whether there is a causal relationship between increased levels of TGF-beta1 and cardiac hypertrophy. Echocardiographic analysis revealed that TGF-beta1-deficient mice subjected to chronic subpressor doses of Ang II had no significant change in left ventricular (LV) mass and percent fractional shortening during Ang II treatment. In contrast, Ang II-treated wild-type mice showed a >20% increase in LV mass and impaired cardiac function. Cardiomyocyte cross-sectional area was also markedly increased in Ang II-treated wild-type mice but unchanged in Ang II-treated TGF-beta1-deficient mice. No significant levels of fibrosis, mitotic growth, or cytokine infiltration were detected in Ang II-treated mice. Atrial natriuretic factor expression was approximately 6-fold elevated in Ang II-treated wild-type, but not TGF-beta1-deficient mice. However, the alpha- to beta-myosin heavy chain switch did not occur in Ang II-treated mice, indicating that isoform switching is not obligatorily coupled with hypertrophy or TGF-beta1. The Ang II effect on hypertrophy was shown not to result from stimulation of the end...Continue Reading

References

Nov 1, 1979·Nature·A M LompreB Swynghedauw
May 1, 1979·The Journal of Endocrinology·J P CoghlanR D Wright
Jan 11, 1975·Catheterization and Cardiovascular Diagnosis·W J RogersC E Rackley
Feb 1, 1990·The Journal of Clinical Investigation·T G ParkerM D Schneider
May 1, 1990·Circulation·M D Schneider, T G Parker
Jan 1, 1991·Annual Review of Physiology·T G Parker, M D Schneider
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Dec 22, 1989·Cell·D G SchatzD Baltimore
Jan 1, 1988·Growth Factors·N L ThompsonM B Sporn
Jul 1, 1983·Circulation Research·J J MercadierK Schwartz
Aug 1, 1981·Circulation Research·J J MercadierK Schwartz
Jan 1, 1995·Connective Tissue Research·R N D'Souza, M Litz
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·T Brand, M D Schneider
Oct 1, 1994·The Journal of Clinical Investigation·N TakahashiW S Colucci
Jan 1, 1994·Journal of Molecular and Cellular Cardiology·P M ButtrickJ Scheuer
Nov 1, 1993·Circulation Research·W R MacLellanM D Schneider
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
Oct 1, 1995·Journal of Molecular and Cellular Cardiology·A A LeeF J Villarreal
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·R J DieboldT Doetschman
Jan 1, 1996·Biological Signals·G YangY Zhu
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·D D D'AngeloG W Dorn
Apr 30, 1998·Circulation Research·K L VikstromL A Leinwand
Mar 26, 1999·Molecular Reproduction and Development·S KallapurT Doetschman
Sep 24, 1999·The Journal of Clinical Investigation·J E SchultzT Doetschman
Dec 13, 2000·Journal of Molecular and Cellular Cardiology·R PatelA J Marian
Apr 18, 2001·Cellular Signalling·M Silberbach, C T Roberts

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Citations

Aug 29, 2012·Cellular and Molecular Life Sciences : CMLS·Jian Wang, Xiao Yang
Sep 29, 2011·Cell and Tissue Research·Thomas DoetschmanMohamad Azhar
May 16, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Craig WongDominic Raj
Sep 28, 2012·Journal of Cardiovascular Translational Research·Melissa L Martin, Burns C Blaxall
Nov 18, 2006·Cardiovascular Research·Marcin Bujak, Nikolaos G Frangogiannis
Apr 6, 2004·Current Opinion in Pharmacology·Akira Matsumori
May 8, 2004·Molecular and Cellular Endocrinology·Ryo ImanishiKatsusuke Yano
Sep 2, 2003·Cytokine & Growth Factor Reviews·Mohamad AzharThomas Doetschman
Sep 18, 2003·Trends in Molecular Medicine·Guido Tarone, Giuseppe Lembo
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathleen M I CaronOliver Smithies
Oct 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kumar PandyaOliver Smithies
Mar 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Masao KakokiOliver Smithies
Jul 9, 2010·International Journal of Endocrinology·Gabriela Placoná DinizMaria Luiza Morais Barreto-Chaves
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Shin-ichi TanakaHiroaki Shimokawa
Jan 9, 2010·Circulation Research·Rahul Kakkar, Richard T Lee
Mar 31, 2012·Circulation Research·Ying Tian, Edward E Morrisey
Oct 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Adam M GoldsmithMarc B Hershenson
Mar 20, 2002·The Journal of Clinical Investigation·Michael D Schneider
May 4, 2011·The Journal of Clinical Investigation·Norimichi KoitabashiDavid A Kass
Nov 6, 2012·Heart Failure Reviews·Ana Maria SeguraL Maximilian Buja
Feb 18, 2014·The Journal of Clinical Investigation·Jason R CookFrancesco Ramirez
Jun 7, 2013·Basic Research in Cardiology·Katsuhito Fujiu, Ryozo Nagai
May 18, 2010·Journal of the American Society of Hypertension : JASH·Jesus L AlmendralSteven A Atlas
May 2, 2008·Medical Hypotheses·Ali A SovariHrayr S Karagueuzian
Jun 16, 2009·European Journal of Clinical Investigation·U SeelandM Böhm
May 31, 2011·Experimental Physiology·Alicia D'SouzaJaipaul Singh
Oct 27, 2004·Trends in Biochemical Sciences·Tetsuro WakatsukiElliot L Elson
May 3, 2016·Heart, Lung & Circulation·Beverly GiamNiwanthi W Rajapakse
May 31, 2016·The American Journal of the Medical Sciences·Richard N Re

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Datasets Mentioned

BETA
K02781

Methods Mentioned

BETA
dissecting
PCR
electrophoresis

Software Mentioned

NIH Scion Image

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